Evidence map›Paper›PMID 34142330›Full record

Observational studyPaediatric drugs2021

Assessment of the Effects of a High Amikacin Dose on Plasma Peak Concentration in Critically Ill Children.

Rym Medjebeur Hanna, Michael Levy, Emmanuelle Bille, Carole Hennequin, Fabrice Lesage, Jérôme Naudin, Florence Moulin, Marie Blanquer, Agathe Béranger, Sylvain Renolleau and 2 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Paediatric drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Rym Medjebeur HannaService de Réanimation et Surveillance Continue Médico-chirugicale Pédiatriques, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France.
Michael LevyService de Réanimation et Surveillance Continue Pédiatriques, Hôpital Robert Debré, Assistance Publique- Hôpitaux de Paris, Université Paris Diderot, Paris, France.
Emmanuelle BilleService de Microbiologie, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France.
Carole HennequinService de Biochimie Générale, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France.
Fabrice LesageService de Réanimation et Surveillance Continue Médico-chirugicale Pédiatriques, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France.
Jérôme NaudinService de Réanimation et Surveillance Continue Pédiatriques, Hôpital Robert Debré, Assistance Publique- Hôpitaux de Paris, Université Paris Diderot, Paris, France.
Florence MoulinService de Réanimation et Surveillance Continue Médico-chirugicale Pédiatriques, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France.
Marie BlanquerService de Pharmacologie Pédiatrique et Pharmacogénétique, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France.
Agathe BérangerService de Réanimation et Surveillance Continue Médico-chirugicale Pédiatriques, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France.
Sylvain RenolleauService de Réanimation et Surveillance Continue Médico-chirugicale Pédiatriques, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France.
Mehdi OualhaService de Réanimation et Surveillance Continue Médico-chirugicale Pédiatriques, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France.
Mathieu GenuiniService de Réanimation et Surveillance Continue Médico-chirugicale Pédiatriques, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France. mathieu.genuini@hotmail.fr.ORCID http://orcid.org/0000-0001-8075-5822
Hôpital Necker-Enfants Malades · FRDélégation Paris 7 · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to assess the incidence of amikacin plasma peak concentration (C

methodsA retrospective observational study was performed in two French pediatric intensive care units. All admitted children who received 30 mg·kg

resultsIn total, 30 patients were included, aged from 3 weeks to 7 years. They received a median amikacin dosage of 30 mg kg

conclusionsDespite the administration of the maximal recommended amikacin dose, C

Indexed as

Acute Kidney InjuryAmikacinAnti-Bacterial AgentsBody WeightChildChild, PreschoolCohort StudiesCritical IllnessFemaleHumansInfantInfant, NewbornMaleMicrobial Sensitivity TestsRetrospective StudiesAmikacinAnti-Bacterial Agents

Identifiers

PMID34142330
OpenAlexW3166377114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.