Evidence map›Paper›PMID 34142303›Full record

ArticleJournal of natural medicines2021

Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron.

Kanji Niwa, Naonobu Tanaka, Yusei Shimomoto, Daisuke Tsuji, Sang-Yong Kim, Mareshige Kojoma, Kohji Itoh, Chin-Ho Chen, Kuo-Hsiung Lee, Yoshiki Kashiwada

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kanji NiwaGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.ORCID http://orcid.org/0000-0003-0772-0935
Naonobu TanakaGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan. ntanak@tokushima-u.ac.jp.ORCID http://orcid.org/0000-0002-9281-7098
Yusei ShimomotoGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Daisuke TsujiGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.ORCID http://orcid.org/0000-0002-1528-7820
Sang-Yong KimFaculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Tobetsu, 061-0293, Japan.ORCID http://orcid.org/0000-0001-9520-2577
Mareshige KojomaFaculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Tobetsu, 061-0293, Japan.ORCID http://orcid.org/0000-0002-4395-4977
Kohji ItohGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.ORCID http://orcid.org/0000-0002-2953-5530
Chin-Ho ChenMedical Center, Duke University, Durham, NC, 27710, USA.ORCID http://orcid.org/0000-0001-6880-2104
Kuo-Hsiung LeeEshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599-7568, USA.ORCID http://orcid.org/0000-0002-6562-0070
Yoshiki KashiwadaGraduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan. kasiwada@tokushima-u.ac.jp.ORCID http://orcid.org/0000-0002-5429-3211

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Six dibenzo-1,4-dioxane derivatives (1-6) were isolated from the roots of a Hypericaceous plant Hypericum ascyron. Spectroscopic analyses revealed 2 and 4-6 to be new compounds. The partial racemic natures of 1-3 were concluded by chiral HPLC analyses, while 5 was confirmed to be a racemate. The absolute configurations 1-4 were deduced on the basis of ECD calculations. Biological activity evaluation of the dibenzo-1,4-dioxane derivatives along with two related compounds: hyperdioxanes A (7) and B (8), previously isolated from the same plant material by our group demonstrated that 7 exhibit an anti-HIV activity (IC

Indexed as

HypericumDioxanesMolecular StructurePlant Roots1,4-dioxaneDioxanesAnti-HIV activityAnti-neuroinflammatory activityDibenzo-1,4-dioxane derivativesHyperdioxanesHypericum ascyron

Identifiers

PMID34142303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.