Evidence map›Paper›PMID 34142276›Full record

ArticleAnnals of biomedical engineering2021

Genetic Mutations Associated with Hormone-Positive Breast Cancer in a Small Cohort of Ethiopian Women.

Alyssa D Schwartz, Afua Adusei, Solomon Tsegaye, Christopher A Moskaluk, Sallie S Schneider, Manu O Platt, Daniel Seifu, Shelly R Peyton, Courtney C Babbitt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Alyssa D Schwartz *Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA, USA.
Afua Adusei *Molecular and Cell Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA, USA.
Solomon TsegayeDepartment of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Christopher A MoskalukDepartment of Pathology, University of Virginia Health System, Charlottesville, VA, USA.
Sallie S SchneiderMolecular and Cell Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA, USA.
Manu O PlattWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 950 Atlantic Drive, Suite 3015, Atlanta, GA, 30332, USA.
Daniel SeifuDepartment of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Shelly R PeytonDepartment of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA, USA. speyton@umass.edu.ORCID http://orcid.org/0000-0002-7364-8727
Courtney C BabbittMolecular and Cell Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA, USA. cbabbitt@bio.umass.edu.
University of Massachusetts Amherst · USAddis Ababa University · ETGeorgia Institute of Technology · USPioneer (United States) · USUniversity of Global Health Equity · RWUniversity of Virginia Health System · US

Funding

Tissue-specific stem cells and breast cancer tissue tropism in bioengineered microenvironmentsDP2CA186573 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI PEYTON, SHELLY R. · 2013 to 2015
$2.6M
A Synthetic Bone Marrow to Understand Breast Cancer DormancyR21CA223783 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI PEYTON, SHELLY R. · 2018 to 2019
$350k
Division of Materials Research DMR1454806National Science Foundation 1451512NCI NIH HHS DP2 CA186573NCI NIH HHS DP2CA186573NCI NIH HHS R21 CA223783NCI NIH HHS R21CA223783
6 · The paper itself

Abstract

In Ethiopia, a breast cancer diagnosis is associated with a prognosis significantly worse than that of Europe and the US. Further, patients presenting with breast cancer in Ethiopia are far younger, on average, and patients are typically diagnosed at very late stages, relative to breast cancer patients of European descent. Emerging data suggest that a large proportion of Ethiopian patients have hormone-positive (ER

Indexed as

Genes, NeoplasmMutationAdolescentAdultAgedAged, 80 and overChildChild, PreschoolEthiopiaFemaleHumansInfantMiddle AgedNeoplasm MetastasisTriple Negative Breast NeoplasmsBRCAExtracellular matrixMAPKMetastasisTCGA

Identifiers

PMID34142276
PMCPMC9703640
OpenAlexW3170496272

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.