Evidence map›Paper›PMID 34142230›Full record

SynthesisWorld journal of urology2022

Incidence, predictive factors and oncological outcomes of incidental prostate cancer after endoscopic enucleation of the prostate: a systematic review and meta-analysis.

Bryan Kwun-Chung Cheng, Daniele Castellani, Ivan Sik-Hei Chan, Abu Baker, Vineet Gauhar, Marcelo Langer Wroclawski, Hegel Trujillo Santamaria, Yiloren Tanidir, Dmitry Enikeev, Vinson Wai-Shun Chan and 3 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  6. Rates of incidental prostate cancer following HoLEP Can it be predicted preoperatively?Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026
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  10. Characteristics of incidental prostate cancer in the United States.Prostate cancer and prostatic diseases · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 9 countries.

Bryan Kwun-Chung ChengDepartment of Surgery, United Christian Hospital, Hong Kong, China. bryan.ckc@gmail.com.
Daniele CastellaniDepartment of Urology, University Hospital "Ospedali Riuniti" and Polytechnic University of Marche Region, Ancona, Italy.
Ivan Sik-Hei ChanS.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Abu BakerS.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Vineet GauharDepartment of Urology, Ng Teng Fong General Hospital, NUHS, Jurong East, Singapore.
Marcelo Langer WroclawskiHospital Israelita Albert Einstein, Sao Paulo, Brazil.
Hegel Trujillo SantamariaHospital Covadonga, Corporativo De Hospitalea S.A. de C.V., Córdoba, Mexico.
Yiloren TanidirDepartment of Urology, Marmara University School of Medicine, İstanbul, Turkey.
Dmitry EnikeevInstitute for Urology and Reproductive Health, Sechenov University, Moscow, Russia.
Vinson Wai-Shun ChanS.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Chi-Fai NgS.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Thomas HerrmannDepartment of Urology, Spital Thurgau AG, Frauenfeld, Switzerland.
Jeremy Yuen-Chun TeohS.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China. jeremyteoh@surgery.cuhk.edu.hk.ORCID http://orcid.org/0000-0002-9361-2342
Chinese University of Hong Kong · HKHospital Israelita Albert Einstein · BRMarche Polytechnic University · ITMarmara University · TRMedizinische Hochschule Hannover · DENg Teng Fong General Hospital · SGSechenov University · RUUnited Christian Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis systematic review aims at reporting the incidence, predictive factors, and the oncological outcomes of incidental prostate cancer (IPCa) in men who underwent endoscopic enucleation of prostate (EEP).

methodsA literature search was performed using the following Medical Subject Heading (MeSH) terms and keywords: "Prostatic Neoplasms", "Prostate Cancer", "Transurethral Resection of Prostate", "Prostate resection", "Prostate enucleation". Meta-analysis was performed if there were two or more studies reporting the same outcome under the same definition. In case of insufficient data, results were presented in a narrative manner.

resultsSixty-one studies were included in qualitative synthesis and 55 were included in meta-analysis. The pooled IPCa rate was 0.08 (95% CI 0.073-0.088). Increasing age, higher preoperative serum prostate-specific antigen (PSA) level, higher preoperative PSA density (PSAD), smaller prostate volume, higher postoperative PSA velocity and lower enucleated prostate weight, were reported to have significant correlation with IPCa. In BPH patients, the mean pre-operative and post-operative PSA levels were 5.58 ± 1.48 ng/dL and 1.06 ± 0.27 ng/dL, respectively. In patients with IPCa, the mean pre-operative and post-operative PSA levels were 7.72 ± 2.90 ng/dL and 2.77 ± 1.66 ng/dL, respectively. The mean percentage PSA reduction was 82.0% ± 1.8% for BPH patients and 68.2% ± 12.1% for IPCa patients. IPCa was most commonly managed by active surveillance (68.7%).

conclusionsThe pooled incidence of IPCa after EEP was 8%. An absolute post-operative PSA level of < 2.0 and a percentage PSA reduction of > 70% should be expected in BPH patients after EEP.

Indexed as

EndoscopyProstatectomyHumansIncidenceIncidental FindingsMaleProstatic HyperplasiaProstatic Neoplasms

Identifiers

PMID34142230
OpenAlexW3169784051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.