Evidence map›Paper›PMID 34142214›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Effects of chronic voluntary alcohol consumption on PDE10A availability: a longitudinal behavioral and [

Bart de Laat, Yvonne E Kling, Gwen Schroyen, Maarten Ooms, Jacob M Hooker, Guy Bormans, Koen Van Laere, Jenny Ceccarini

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Bart de Laat *Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Yvonne E Kling *Department of Neurosciences, KU Leuven, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.
Gwen SchroyenDepartment of Imaging and Pathology, Translational MRI, KU Leuven, Leuven, Belgium.
Maarten OomsLaboratory for Radiopharmaceutical Research, KU Leuven, Leuven, Belgium.
Jacob M HookerAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Guy BormansLaboratory for Radiopharmaceutical Research, KU Leuven, Leuven, Belgium.
Koen Van LaereNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Jenny CeccariniNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. jenny.ceccarini@uzleuven.be.ORCID http://orcid.org/0000-0003-2774-9516
KU Leuven · BEHarvard University · USVIB-KU Leuven Center for Brain & Disease Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePhosphodiesterase 10A (PDE10A) is a dual substrate enzyme highly enriched in dopamine-receptive striatal medium spiny neurons, which are involved in psychiatric disorders such as alcohol use disorders (AUD). Although preclinical studies suggest a correlation of PDE10A mRNA expression in neuronal and behavioral responses to alcohol intake, little is known about the effects of alcohol exposure on in vivo PDE10A activity in relation to apparent risk factors for AUD such as decision-making and anxiety.

methodsWe performed a longitudinal [

resultsWe observed an increased alcohol preference especially in those animals that exhibited poor initial decision-making. The first 2 weeks of alcohol exposure resulted in an increased striatal PDE10A binding (> 10%). Comparing PDE10A-binding potential after 2 versus 4 weeks of exposure showed a significant decreased PDE10A in the caudate-putamen and nucleus accumbens (p

conclusionThis study shows that chronic voluntary alcohol consumption induces a reversible increased PDE10A enzymatic availability in the striatum, which is related to the amount of alcohol preference. Thus, PDE10A-mediated signaling plays an important role in modulating the reinforcing effects of alcohol, and the data suggest that PDE10A inhibition may have beneficial behavioral effects on alcohol intake.

Indexed as

AlcoholismPositron-Emission TomographyAlcohol DrinkingAnimalsBrainPhosphoric Diester HydrolasesPyrazolesPyridinesRats2-((4-(1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridinePhosphoric Diester HydrolasesPyrazolesPyridines[18F]JNJ42259152Alcohol preferenceMicroPETOpen-field testPhosphodiesterase 10ARat Iowa Gambling Task

Identifiers

PMID34142214
OpenAlexW3138282238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.