ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2021
Large-scale integration of meta-QTL and genome-wide association study discovers the genomic regions and candidate genes for yield and yield-related traits in bread wheat.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 15 of them syntheses that pooled it.
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Who cites it
89 citing papers in PubMed, 15 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Unravelling consensus genomic regions conferring stem-related traits in wheat via meta-QTL analysis.BMC plant biology · 2025Pooled it
- Unraveling the genetic basis of quantitative resistance to diseases in tomato: a meta-QTL analysis and mining of transcript profiles.Plant cell reports · 2024Pooled it
- Meta QTL analysis for dissecting abiotic stress tolerance in chickpea.BMC genomics · 2024Pooled it
- Meta-Quantitative Trait Loci Analysis and Candidate Gene Mining for Drought Tolerance-Associated Traits in Maize (International journal of molecular sciences · 2024Pooled it
- Meta-analysis of seed weight QTLome using a consensus and highly dense genetic map in Brassica napus L.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Pooled it
- Consensus genomic regions for grain quality traits in wheat revealed by Meta-QTL analysis and in silico transcriptome integration.The plant genome · 2023Pooled it
- Genome-Wide Meta-Analysis of QTLs Associated with Root Traits and Implications for Maize Breeding.International journal of molecular sciences · 2023Pooled it
- Meta-QTL analysis and in-silico transcriptome assessment for controlling chlorophyll traits in common wheat.The plant genome · 2023Pooled it
- Genome-wide association study to identify genomic loci associated with early vigor in bread wheat under simulated water deficit complemented with quantitative trait loci meta-analysis.G3 (Bethesda, Md.) · 2023Pooled it
- Deciphering key genomic regions controlling flag leaf size in wheat via integration of meta-QTL and in silico transcriptome assessment.BMC genomics · 2023Pooled it
- Identification of quantitative trait loci (QTL) and meta-QTL analysis for kernel size-related traits in wheat (Triticum aestivum L.).BMC plant biology · 2022Pooled it
- Genome-wide meta-QTL analyses provide novel insight into disease resistance repertoires in common bean.BMC genomics · 2022Pooled it
- Consensus genomic regions associated with multiple abiotic stress tolerance in wheat and implications for wheat breeding.Scientific reports · 2022Pooled it
- Pooled it
- Genome-wide meta-analysis of QTL for morphological related traits of flag leaf in bread wheat.PloS one · 2022Pooled it
- Unveiling core genomic regions shaping plant architecture, productivity, and seed quality traits in sesame (Sesamum indicum L.): insights from Meta-QTL study into breeding targets.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Genetic dissection of cold stress tolerance and yield potential under cold stress in nested synthetic wheat (Triticum aestivum L.) introgression libraries using multi-locus genome-wide association and haplotype analysis.Functional & integrative genomics · 2026Article
- Genetic modulation of yield and phenotypic plasticity of yield in winter wheat.Journal of experimental botany · 2026Article
- Quantitative trait loci associated with drought stress tolerance in wheat primed with zinc oxide nanoparticles at seed germination and seedling stages.Scientific reports · 2026Article
- Genome-Wide Association Study on Lodging Resistance-Related Traits in Oats.Plants (Basel, Switzerland) · 2026Article
29 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
key messageBased on the large-scale integration of meta-QTL and Genome-Wide Association Study, 76 high-confidence MQTL regions and 237 candidate genes that affected wheat yield and yield-related traits were discovered. Improving yield and yield-related traits are key goals in wheat breeding program. The integration of accumulated wheat genetic resources provides an opportunity to uncover important genomic regions and candidate genes that affect wheat yield. Here, a comprehensive meta-QTL analysis was conducted on 2230 QTL of yield-related traits obtained from 119 QTL studies. These QTL were refined into 145 meta-QTL (MQTL), and 89 MQTL were verified by GWAS with different natural populations. The average confidence interval (CI) of these MQTL was 2.92 times less than that of the initial QTL. Furthermore, 76 core MQTL regions with a physical distance less than 25 Mb were detected. Based on the homology analysis and expression patterns, 237 candidate genes in the MQTL involved in photoperiod response, grain development, multiple plant growth regulator pathways, carbon and nitrogen metabolism and spike and flower organ development were determined. A novel candidate gene TaKAO-4A was confirmed to be significantly associated with grain size, and a CAPS marker was developed based on its dominant haplotype. In summary, this study clarified a method based on the integration of meta-QTL, GWAS and homology comparison to reveal the genomic regions and candidate genes that affect important yield-related traits in wheat. This work will help to lay a foundation for the identification, transfer and aggregation of these important QTL or candidate genes in wheat high-yield breeding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.