Evidence map›Paper›PMID 34142122›Full record

Trial reportRheumatology (Oxford, England)2021

Ticagrelor added to methotrexate improves rheumatoid arthritis disease severity.

Michael S Garshick, Pamela B Rosenthal, Elliot Luttrell-Williams, Bruce N Cronstein, Jeffrey S Berger

Abstract readClinical Trial
In one paragraph

Trial report in Rheumatology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. The Signaling Pathway of the ADP Receptor P2YInternational journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael S GarshickCenter for the Prevention of Cardiovascular Disease, Department of Medicine.ORCID 0000-0002-6649-3755
Pamela B RosenthalDivision of Rheumatology, Department of Medicine.
Elliot Luttrell-WilliamsLeon H. Charney Division of Cardiology, Department of Medicine.
Bruce N CronsteinDivision of Rheumatology, Department of Medicine.
Jeffrey S BergerCenter for the Prevention of Cardiovascular Disease, Department of Medicine.

Funding

Institutional Clinical and Translational Science AwardUL1TR000038 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL · 2012 to 2014
$16.8M
Training Program in Cardiovascular SciencesT32HL098129 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Glenn I Fishman, Ira J Goldberg · 2009 to 2026
$5.9M
Mechanisms of Platelet Activity in Vascular DiseaseR35HL144993 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BERGER, JEFFREY S · 2019 to 2025
$5.5M
The Pharmacology of Dermal Fibrosis R01AR056672 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL · 2009 to 2018
$4.6M
Platelet Activity and Vascular Health in Systemic Lupus ErythematosusR01HL139909 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BERGER, JEFFREY S, BUYON, JILL P · 2018 to 2022
$4.3M
Purinergic Regulation of Bone MetabolismR01AR054897 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL · 2008 to 2014
$2.1M
Endovascular Health and Platelet Activity in PsoriasisK23HL152013 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GARSHICK, MICHAEL SETH · 2021 to 2025
$865k
NCATS NIH HHS UL1 TR000038NHLBI NIH HHS K23 HL152013NHLBI NIH HHS R01 HL139909NHLBI NIH HHS R35 HL144993NHLBI NIH HHS T32 HL098129NIAMS NIH HHS R01 AR054897NIAMS NIH HHS R01 AR056672NIH HHS
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAntirheumatic AgentsArthritis, RheumatoidDrug Therapy, CombinationFemaleHumansMaleMethotrexateMiddle AgedProof of Concept StudyPurinergic P2Y Receptor AntagonistsSeverity of Illness IndexTicagrelorAntirheumatic AgentsMethotrexatePurinergic P2Y Receptor AntagonistsTicagrelor

Identifiers

PMID34142122
PMCPMC8783537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.