Evidence map›Paper›PMID 34142048›Full record

ArticleiScience2021

A refined genome phage display methodology delineates the human antibody response in patients with Chagas disease.

André Azevedo Reis Teixeira, Luis Rodriguez Carnero, Andréia Kuramoto, Fenny Hui Fen Tang, Carlos Hernique Gomes, Natalia Bueno Pereira, Léa Campos de Oliveira, Regina Garrini, Jhonatas Sirino Monteiro, João Carlos Setubal and 7 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Recent Progress in Antibody Epitope Prediction.Antibodies (Basel, Switzerland) · 2023
    Review
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

André Azevedo Reis TeixeiraDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
Luis Rodriguez CarneroDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
Andréia KuramotoHeart Institute (InCor), University of São Paulo School of Medicine, São Paulo, SP, 05403-000, Brazil.
Fenny Hui Fen TangDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
Carlos Hernique GomesDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
Natalia Bueno PereiraHeart Institute (InCor), University of São Paulo School of Medicine, São Paulo, SP, 05403-000, Brazil.
Léa Campos de OliveiraInstitute of Tropical Medicine, University of São Paulo School of Medicine, São Paulo, SP, 05403-000, Brazil.
Regina GarriniInstitute of Tropical Medicine, University of São Paulo School of Medicine, São Paulo, SP, 05403-000, Brazil.
Jhonatas Sirino MonteiroDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
João Carlos SetubalDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
Ester Cerdeira SabinoInstitute of Tropical Medicine, University of São Paulo School of Medicine, São Paulo, SP, 05403-000, Brazil.
Renata PasqualiniRutgers Cancer Institute of New Jersey, Newark, NJ 07103, USA.
Walter ColliDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
Wadih ArapRutgers Cancer Institute of New Jersey, Newark, NJ 07103, USA.
Maria Júlia Manso AlvesDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
Edécio Cunha-NetoHeart Institute (InCor), University of São Paulo School of Medicine, São Paulo, SP, 05403-000, Brazil.
Ricardo José GiordanoDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.
Universidade de São Paulo · BRRutgers, The State University of New Jersey · US

Funding

Sao Paulo-Minas Gerais Tropical Medicine Research Center for Chagas Disease Biomarker DiscoveryU19AI098461 · NIAID · FUNDACAO FACULDADE DE MEDICINA · PI SABINO, ESTER CERDEIRA · 2017 to 2021
$2.1M
"Sao Paulo-Minas Gerais Center for Chagas Disease Treatment (SaMiTrop)"U01AI168383 · NIAID · FUNDACAO FACULDADE DE MEDICINA · PI Ester Cerdeira Sabino · 2022 to 2026
$1.9M
NIAID NIH HHS U01 AI168383NIAID NIH HHS U19 AI098461
6 · The paper itself

Abstract

Large-scale mapping of antigens and epitopes is pivotal for developing immunotherapies but challenging, especially for eukaryotic pathogens, owing to their large genomes. Here, we developed an integrated platform for genome phage display (gPhage) to show that unbiased libraries of the eukaryotic parasite

Indexed as

ParasitologySequence AnalysisSystems Biology

Identifiers

PMID34142048
PMCPMC8185243
OpenAlexW3162138669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.