ArticleiScience2021
Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Effects of time-restricted feeding and walking exercise on the physical health of female college students with hidden obesity: a randomized trial.Frontiers in public health · 2023Trial
- Chronic Caffeine Consumption Prevents Body Weight Gain and Glucose Intolerance in High-Fat Diet-Induced Obesity Mice Model.Metabolites · 2026Article
- Short-term time-restricted feeding improves metabolic rhythms and liver mitochondrial bioenergetic function in high-fat diet-fed mice.Function (Oxford, England) · 2026Article
- Molecular Links Between Circadian Rhythm Disruption, Melatonin, and Neurodegenerative Diseases: An Updated Review.Molecules (Basel, Switzerland) · 2025Review
- I "Gut" Rhythm: the microbiota as a modulator of the stress response and circadian rhythms.The FEBS journal · 2025Review
- Smart Lids for deep multi-animal phenotyping in standard home cages.Frontiers in behavioral neuroscience · 2025Article
- Time-restricted feeding prevents memory impairments induced by obesogenic diet consumption, via hippocampal thyroid hormone signaling.Molecular metabolism · 2024Article
- Time-restricted eating improves health because of energy deficit and circadian rhythm: A systematic review and meta-analysis.iScience · 2024Article
- Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine.Neuroscience and biobehavioral reviews · 2024Review
- Time-restricted feeding and Alzheimer's disease: you are when you eat.Trends in molecular medicine · 2023Article
- Fasting: From Physiology to Pathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Finding balance: understanding the energetics of time-restricted feeding in mice.Obesity (Silver Spring, Md.) · 2023Review
- Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet.Cell metabolism · 2023Article
- Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors.Nutrients · 2022Review
- Circadian disruption of hippocampus in an early senescence male mouse model.Pharmacology, biochemistry, and behavior · 2022Article
- Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders.Cell metabolism · 2022Article
- Obese mice induced by high-fat diet have differential expression of circular RNAs involved in endoplasmic reticulum stress and neuronal synaptic plasticity of hippocampus leading to obesity-associated cognitive impairment.Frontiers in molecular neuroscience · 2022Article
- The association of diet carbohydrates consumption with cognitive function among US older adults modification by daily fasting duration.Frontiers in aging neuroscience · 2022Article
- A Bibliometric and Visualization Analysis of Intermittent Fasting.Frontiers in public health · 2022Article
- Post-oral sensing of fat increases food intake and attenuates body weight defense.Cell reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Feeding rodents a high-fat diet (HFD) disrupts normal behavioral rhythms, particularly meal timing. Within the brain, mistimed feeding shifts molecular rhythms in the hippocampus and impairs memory. We hypothesize that altered meal timing induced by an HFD leads to cognitive impairment and that restricting HFD access to the "active period" (i.e., night) rescues the normal hippocampal function. In male mice,
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.