Evidence map›Paper›PMID 34142028›Full record

ArticleiScience2021

Lemon exosome-like nanoparticles enhance stress survival of gut bacteria by RNase P-mediated specific tRNA decay.

Chao Lei, Yun Teng, Liqing He, Mohammed Sayed, Jingyao Mu, Fangyi Xu, Xiangcheng Zhang, Anil Kumar, Kumaran Sundaram, Mukesh K Sriwastva and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 2 countries.

Chao LeiJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309 505 Hancock Street, Louisville, KY 40202, USA.
Yun TengJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309 505 Hancock Street, Louisville, KY 40202, USA.
Liqing HeKidney Disease Program and Clinical Proteomics Center, University of Louisville, Louisville, KY, USA.
Mohammed SayedDepartment of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40202, USA.
Jingyao MuJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309 505 Hancock Street, Louisville, KY 40202, USA.
Fangyi XuJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309 505 Hancock Street, Louisville, KY 40202, USA.
Xiangcheng ZhangDepartment of ICU, the Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, China.
Anil KumarJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309 505 Hancock Street, Louisville, KY 40202, USA.
Kumaran SundaramJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309 505 Hancock Street, Louisville, KY 40202, USA.
Mukesh K SriwastvaJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309 505 Hancock Street, Louisville, KY 40202, USA.
Lifeng ZhangJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309 505 Hancock Street, Louisville, KY 40202, USA.
Shao-Yu ChenDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
Wenke FengDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Shuangqin ZhangPeeples Cancer Institute, 215 Memorial Drive, Dalton, GA 30720, USA.
Jun YanJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309 505 Hancock Street, Louisville, KY 40202, USA.
Juw Won ParkDepartment of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40202, USA.
Michael L MerchantKidney Disease Program and Clinical Proteomics Center, University of Louisville, Louisville, KY, USA.
Xiang ZhangKidney Disease Program and Clinical Proteomics Center, University of Louisville, Louisville, KY, USA.
Huang-Ge ZhangRobley Rex Veterans Affairs Medical Center, Louisville, KY 40206, USA.
University of Louisville · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative IntravaginalP20GM125504 · NIGMS · UNIVERSITY OF LOUISVILLE · PI Shirin Ghods · 2018 to 2026
$24.4M
Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
Plant exosomes non-coding RNA-mediated anti-inflammatory mechanismsR01AT008617 · NCCIH · UNIVERSITY OF LOUISVILLE · PI HUANG-GE ZHANG · 2016 to 2026
$5.7M
National Glycoscience Resource- CCRC Service and Training - NGlycoR@CCRCR24GM137782 · NIGMS · UNIVERSITY OF GEORGIA · PI Parastoo Azadi · 2020 to 2026
$5.2M
Mechanisms of Probiotics in Alcoholic Liver DiseaseR01AA023190 · NIAAA · UNIVERSITY OF LOUISVILLE · PI FENG, WENKE · 2015 to 2024
$3.5M
Role of exosomes in the coordinated migration of neural crest cells and placodes and ethanol-induced teratogenesisR01AA028435 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CHEN, SHAO-YU · 2020 to 2024
$1.8M
NCCIH NIH HHS R01 AT008617NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA023190NIAAA NIH HHS R01 AA028435NIEHS NIH HHS P30 ES030283NIGMS NIH HHS P20 GM103436NIGMS NIH HHS P20 GM113226NIGMS NIH HHS P20 GM125504NIGMS NIH HHS R24 GM137782
6 · The paper itself

Abstract

Diet and bile play critical roles in shaping gut microbiota, but the molecular mechanism underlying interplay with intestinal microbiota is unclear. Here, we showed that lemon-derived exosome-like nanoparticles (LELNs) enhance lactobacilli toleration to bile. To decipher the mechanism, we used

Indexed as

MicrobiologyMolecular biologyNanoparticles

Identifiers

PMID34142028
PMCPMC8188359
OpenAlexW3157155693

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.