Evidence map›Paper›PMID 34142024›Full record

ArticleiScience2021

Zebrafish harbor diverse intestinal macrophage populations including a subset intimately associated with enteric neural processes.

Christina L Graves, Angela Chen, Victoria Kwon, Celia E Shiau

Abstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. ThemBio · 2025
    Article
  4. Article
  5. Article
  6. Infection of endemic chubParasitology · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christina L GravesDepartment of Biology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.
Angela ChenDepartment of Biology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.
Victoria KwonDepartment of Biology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.
Celia E ShiauDepartment of Biology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.

Funding

BASIC IMMUNE MECHANISMST32AI007273 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 1985 to 2020
$5.6M
Genetic and metabolic regulation of macrophage activation at steady stateR35GM124719 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Celia E Shiau · 2017 to 2026
$4.6M
NIAID NIH HHS T32 AI007273NIGMS NIH HHS R35 GM124719
6 · The paper itself

Abstract

Intestinal macrophages are essential for gut health but remain understudied outside of human and mouse systems. Here, we establish zebrafish as a powerful model that provides superior imaging capabilities for whole-gut analysis along all dimensions (anterior-posterior and center-outer axes) for dissecting macrophage biology in gastrointestinal health and disease. We utilized high-resolution imaging to show that the zebrafish gut contains

Indexed as

Developmental neuroscienceImmunology

Identifiers

PMID34142024
PMCPMC8185245

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.