Evidence map›Paper›PMID 34142014›Full record

ArticleACS applied nano materials2021

Multicolor Fluorescent Graphene Oxide Quantum Dots for Sensing Cancer Cell Biomarkers.

Lisandro Cunci, Viviana González-Colón, Brenda Lee Vargas-Pérez, Joed Ortiz-Santiago, Miraida Pagán, Paola Carrion, Jomari Cruz, Agustin Molina-Ontoria, Namyr Martinez, Walter Silva and 2 more

Open access · greenAbstract read
In one paragraph

Article in ACS applied nano materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Lisandro CunciDepartment of Chemistry, Universidad Ana G. Méndez, Carr. 189, Km 3.3, Gurabo, Puerto Rico 00778, United States.
Viviana González-ColónDepartment of Physiology, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico 00936, United States.
Brenda Lee Vargas-PérezDepartment of Chemistry, Universidad Ana G. Méndez, Carr. 189, Km 3.3, Gurabo, Puerto Rico 00778, United States.
Joed Ortiz-SantiagoDepartment of Chemistry, Universidad Ana G. Méndez, Carr. 189, Km 3.3, Gurabo, Puerto Rico 00778, United States.
Miraida PagánDepartment of Chemistry, Universidad Ana G. Méndez, Carr. 189, Km 3.3, Gurabo, Puerto Rico 00778, United States.
Paola CarrionDepartment of Chemistry, Universidad Ana G. Méndez, Carr. 189, Km 3.3, Gurabo, Puerto Rico 00778, United States.
Jomari CruzDepartment of Chemistry, Universidad Ana G. Méndez, Carr. 189, Km 3.3, Gurabo, Puerto Rico 00778, United States.
Agustin Molina-OntoriaIMDEA-Nanociencia, C/Faraday, 9 Ciudad Universitaria de Cantoblanco, 28049 Madrid, Spain.
Namyr MartinezDepartment of Physiology, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico 00936, United States.
Walter SilvaDepartment of Physiology, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico 00936, United States.
Luis EchegoyenDepartment of Chemistry, University of Texas at El Paso, El Paso, Texas 79968, United States.
Carlos R CabreraDepartment of Chemistry, University of Puerto Rico - Rio Piedras Campus, 17 Ave. Universidad STE 1701, 6, San Juan, Puerto Rico 00925, United States.
Ana G. Mendez University System · PRUniversity of Puerto Rico, Medical Sciences Campus · PRIMDEA Nanoscience · ESThe University of Texas at El Paso · USUniversity of Puerto Rico at Río Piedras · PR

Funding

SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Humberto Guillermo Ortiz-Zuazaga · 2012 to 2026
$52.9M
Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
NIGMS NIH HHS P20 GM103475NIGMS NIH HHS P30 GM124166
6 · The paper itself

Abstract

Onion-like carbon nanoparticles were synthesized from diamond nanoparticles to be used as the precursor for graphene oxide quantum dots. Onion-like carbon nanoparticles were exfoliated to produce two types of nanoparticles, graphene oxide quantum dots that showed size-dependent fluorescence and highly stable inner cores. Multicolor fluorescent quantum dots were obtained and characterized using different techniques. Polyacrylamide gel electrophoresis showed a range of emission wavelengths spanning from red to blue with the highest intensity shown by green fluorescence. Using high-resolution transmission electron microscopy, we calculated a unit cell size of 2.47 Å in a highly oxidized and defected structure of graphene oxide. A diameter of ca. 4 nm and radius of gyration of ca. 11 Å were calculated using small-angle X-ray scattering. Finally, the change in fluorescence of the quantum dots was studied when single-stranded DNA that is recognized by telomerase was attached to the quantum dots. Their interaction with the telomerase present in cancer cells was observed and a change was seen after six days, providing an important application of these modified graphene oxide quantum dots for cancer sensing.

Indexed as

Cancer sensingFluorescenceGraphene oxide quantum dotsOnion-like carbon nanoparticlesSmall angle X-ray Scattering

Identifiers

PMID34142014
PMCPMC8205432
OpenAlexW3114814445

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.