ArticleJournal of the Endocrine Society2021
Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites.
Article in Journal of the Endocrine Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans.Thyroid : official journal of the American Thyroid Association · 2022Trial
- The Impact of Hypothyroidism on Cardiovascular-Related Healthcare Utilization in the US Population With Diabetes.Journal of the Endocrine Society · 2024Article
- TSH Trajectories During Levothyroxine Treatment in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Cohort.The Journal of clinical endocrinology and metabolism · 2024Article
- Thyroid Hormone Homeostasis in Levothyroxine-treated Patients: Findings From ELSA-Brasil.The Journal of clinical endocrinology and metabolism · 2024Article
- Emerging Therapies in Hypothyroidism.Annual review of medicine · 2024Review
- Critical Approach to Hypothyroid Patients With Persistent Symptoms.The Journal of clinical endocrinology and metabolism · 2023Article
- Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism?Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2023Review
- Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-treated Patients.The Journal of clinical endocrinology and metabolism · 2023Observational
- The relevance of TThe lancet. Diabetes & endocrinology · 2022Review
- Optimal Thyroid Hormone Replacement.Endocrine reviews · 2022Article
- T3 levels and thyroid hormone signaling.Frontiers in endocrinology · 2022Review
- Prediction of SARS-CoV-2-positivity from million-scale complete blood counts using machine learning.Communications medicine · 2022Article
- Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites.Journal of the Endocrine Society · 2021Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
contextTreatment with levothyroxine (LT4) that normalize serum thyrotropin (TSH) is expected to restore lipid metabolism.
objectiveTo assess statin utilization in LT4-treated patients through an observational drug utilization study.
methodsThree sites were involved: (1) 10 723 outpatients placed on LT4 during 2006-2019 identified from the Clinical Research Data Warehouse of the University of Chicago; (2) ~1.4 million LT4 prescriptions prepared by primary care physicians during January-December 2018, identified from the IQVIA™ database of medical prescriptions in Brazil; (30 ~5.4 million patient interviews during 2009-2019, including ~0.32 million patients on LT4, identified from the Fleury Group database in Brazil.
resultsOn site 1, initiation of therapy with LT4 increased the frequency of statin utilization (19.1% vs 24.6%), which occurred ~1.5 years later (median 76 weeks) and, among those patients that were on statins, increased intensity of treatment by 33%, despite normalization of serum TSH levels; on site 2, after matching for sex and age, the frequency of statins prescription was higher for those patients using LT4: females, 2.1 vs 3.4% (odds ratio [OR] 1.656 [1.639-1.673]); males, 3.1 vs 4.4% (OR 1.435 [1.409-1.462]); and, on site 3, after matching for sex and age, the frequency of statin utilization was higher in those patients using LT4: females, 10 vs 18% (OR 2.02 [2.00-2.04]); males, 15 vs 25% (OR 1.92 [1.88-1.96]); all
conclusionPrescription and utilization of statins were higher in patients taking LT4. The reasons for this association should be addressed in future studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.