Evidence map›Paper›PMID 34141981›Full record

ArticleHepatology communications2021

Patient Determinants for Histologic Diagnosis of NAFLD in the Real World: A TARGET-NASH Study.

A Sidney Barritt, Stephanie Watkins, Norman Gitlin, Samuel Klein, Anna S Lok, Rohit Loomba, Cheryl Schoen, K Rajender Reddy, Huy Ngoc Trinh, Andrea R Mospan and 5 more

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Selecting Pharmacologic Interventions for MASH.Digestive diseases and sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 1 country.

A Sidney BarrittDivision of Gastroenterology and HepatologyUNC Liver CenterUniversity of North Carolina at Chapel HillChapel HillNCUSA.ORCID 0000-0002-4200-3256
Stephanie WatkinsTarget RWEDurhamNCUSA.ORCID 0000-0003-3496-7239
Norman GitlinAtlanta Gastroenterology AssociatesAtlantaGAUSA.
Samuel KleinCenter for Human Nutrition and Atkins Center of Excellence in Obesity MedicineWashington University School of MedicineSt. LouisMOUSA.
Anna S LokDivision of Gastroenterology and HepatologyUniversity of MichiganAnn ArborMIUSA.
Rohit LoombaDivision of GastroenterologyDepartment of MedicineUniversity of California at San DiegoCAUSA.
Cheryl SchoenTarget RWEDurhamNCUSA.
K Rajender ReddyDivision of Gastroenterology and HepatologyUniversity of PennsylvaniaPhiladelphiaPAUSA.ORCID 0000-0002-4898-7778
Huy Ngoc TrinhSan Jose GastroenterologySan JoseCAUSA.
Andrea R MospanTarget RWEDurhamNCUSA.ORCID 0000-0002-3419-8276
Miriam B VosSchool of MedicineEmory University Children's Healthcare of AtlantaAtlantaGAUSA.
L Michael WeissGastro FloridaClearwaterFLUSA.
Kenneth CusiDivision of Endocrinology, Diabetes and MetabolismUniversity of FloridaGainesvilleFLUSA.
Brent A Neuschwander-TetriDivision of Gastroenterology and HepatologySaint Louis UniversitySt. LouisMOUSA.
Arun J SanyalDivision of Gastroenterology, Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityVCU Medical Center-MCV CampusWest HospitalRichmondVAUSA.
Target (United States) · USAtkins (United States) · USAtlanta Gastroenterology Associates · USClearwater Christian College · USEmory University · USHospital of the University of Pennsylvania · USKaiser Permanente San Jose Medical Center · USSaint Louis University Hospital · USUniversity of California San Diego · USUniversity of Florida Health · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USVirginia Commonwealth University Medical Center · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

Much of the current data on nonalcoholic fatty liver disease (NAFLD) are derived from biopsy-based studies that may introduce ascertainment and selection bias. Selection of patients for liver biopsy has implications for clinical practice and the reported epidemiology of NAFLD. The aim of this study was to determine patient factors predictive of histologic versus empiric clinical diagnosis of NAFLD in real-world practice. Adults from TARGET-NASH were included in this study. Descriptive statistics are provided for the cohort and compare the characteristics of histologic NAFLD versus patients with clinically diagnosed NAFLD, followed by logistic regression and machine-learning models to describe predictors of liver biopsy. The records of 3,474 subjects were analyzed; median age was 59 years, 59% were female, 75% were White, and median body mass index was 32 kg/m

Identifiers

PMID34141981
PMCPMC8183178
OpenAlexW3132111161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.