Evidence map›Paper›PMID 34141862›Full record

ArticleInternational journal of cardiology. Heart & vasculature2021

Common genetic variation in circadian clock genes are associated with cardiovascular risk factors in an African American and Hispanic/Latino cohort.

Pablo Salazar, Sreenivas Konda, Arvind Sridhar, Zarema Arbieva, Martha Daviglus, Dawood Darbar, Jalees Rehman

Open access · goldAbstract read
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Now is the time to prioritize sleep timing for cardiovascular health.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pablo SalazarDepartment of Medicine, Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.
Sreenivas KondaDivision of Epidemiology and Biostatics, School of Public Health, University of Illinois at Chicago, Chicago, IL, USA.
Arvind SridharDepartment of Medicine, Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.
Zarema ArbievaGenomics Core, Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA.
Martha DaviglusDepartment of Medicine, Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.
Dawood DarbarDepartment of Medicine, Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.
Jalees RehmanDepartment of Medicine, Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.
University of Illinois Chicago · USIllinois College · US

Funding

Integration Free IPS Cells-Derived Progenitors for Cardiac RegenerationR01HL126516 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REHMAN, JALEES · 2015 to 2019
$3.0M
Deciphering the genetic mechanisms of atrial fibrillationR01HL138737 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2017 to 2020
$2.6M
Training Program in Personalized Cardiovascular Medicine (TPIPCVM)T32HL139439 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2018 to 2022
$2.1M
NHLBI NIH HHS R01 HL126516NHLBI NIH HHS R01 HL138737NHLBI NIH HHS T32 HL139439
6 · The paper itself

Abstract

Misalignment of the internal circadian time with external physical time due to environmental factors or due to genetic variantion in circadian clock genes has been associated with increased incidence of cardiovascular risk factors. Common genetic variation in circadian genes in the United States have been identified predominantly in European ancestry individuals. We therefore examined the association between circadian clock single nucleotide polymorphisms (SNPs) in

Indexed as

Cardiovascular DiseaseCircadian rhythmsDiabetesEthnicityGeneticsHypertensionUnderrepresented minorities

Identifiers

PMID34141862
PMCPMC8188044
OpenAlexW3167973310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.