ReviewNeurobiology of stress2021
Molecular impacts of childhood abuse on the human brain.
Review in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Brain network controllability in genetic risk, childhood abuse, and adult anxiety.European journal of psychotraumatology · 2025Article
- The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health.Biology · 2025Review
- Early life stress and functional connectivity in antipsychotic-naïve first episode psychosis patients.Schizophrenia (Heidelberg, Germany) · 2025Article
- Child Maltreatment and Psychopathology: A Brief Review on the Potential Role of the Hypothalamic-pituitary-adrenal Axis.Current pediatric reviews · 2025Review
- Replanting the Birthing Trees to support Aboriginal and Torres Strait Islander parents and babies: protocol for developmental evaluation of a comprehensive culturally responsive, trauma-aware, healing-informed, continuity of care(r) model.Frontiers in public health · 2025Article
- Gastrointestinal symptoms in abused nonpatient women.BMC women's health · 2024Article
- Emotional abuse mediated by negative automatic thoughts impacts functional connectivity during adolescence.Neurobiology of stress · 2024Article
- Adverse Childhood Experiences and the Risk of Multiple Sclerosis Development: A Review of Potential Mechanisms.International journal of molecular sciences · 2024Review
- Article
- Implementing Evidence-Based Suicide Prevention Strategies for Greatest Impact.Focus (American Psychiatric Publishing) · 2023Review
- Genetics and epigenetics of stress: New avenues for an old concept.Neurobiology of stress · 2023Article
- Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences-A Narrative Review.International journal of molecular sciences · 2022Review
- Childhood maltreatment increases the suicidal risk in Chinese schizophrenia patients.Frontiers in psychiatry · 2022Article
- Childhood Emotional Neglect and Cardiovascular Disease: A Narrative Review.Frontiers in cardiovascular medicine · 2022Review
- [Effect of parental emotional neglect on nonZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood abuse (CA) is a prevalent global health concern, increasing the risk of negative mental health outcomes later in life. In the literature, CA is commonly defined as physical, sexual, and emotional abuse, as well as neglect. Several mental disorders have been associated with CA, including depression, bipolar disorder, schizophrenia, and post-traumatic stress disorder, along with an increased risk of suicide. It is thought that traumatic life events occurring during childhood and adolescence may have a significant impact on essential brain functions, which may persist throughout adulthood. The interaction between the brain and the external environment can be mediated by epigenetic alterations in gene expression, and there is a growing body of evidence to show that such changes occur as a function of CA. Disruptions in the HPA axis, myelination, plasticity, and signaling have been identified in individuals with a history of CA. Understanding the molecular impact of CA on the brain is essential for the development of treatment and prevention measures. In this review, we will summarize studies that highlight the molecular changes associated with CA in the human brain, along with supporting evidence from peripheral studies and animal models. We will also discuss some of the limitations surrounding the study of CA and propose extracellular vesicles as a promising future approach in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.