ArticleWorld journal of clinical cases2021
Is it time to put traditional cold therapy in rehabilitation of soft-tissue injuries out to pasture?
Article in World journal of clinical cases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07696949 (Effectiveness of Virtual Reality and Cryotherapy on Postoperative Pain and Anxiety Among Women Undergoing Cesarean Section Under Spinal Anesthesia), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Virtual Reality and Cryotherapy on Postoperative Pain and Anxiety Among Women Undergoing Cesarean Section Under Spinal Anesthesia: A Three-Arm Factorial Randomized Controlled Trial
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effectiveness and safety of heat/cold therapy in adults with lymphoedema: systematic review.Disability and rehabilitation · 2024Pooled it
- A quasi-experimental study on conservative nursing measures for preventing phlebitis in chemotherapy patients.Scientific reports · 2025Trial
- Convection-basedWorld journal of experimental medicine · 2026Article
- Effect of early local cold compression therapy combined with rehabilitation exercises on local swelling and joint function recovery in patients with periarticular ankle fractures.Pakistan journal of medical sciences · 2026Article
- Comparative Evaluation of Pain Perception and Postoperative Pain in Children with Precooled Injection Sites Using Popsicles for Local Anesthesia: A Randomized Controlled Trial.International journal of clinical pediatric dentistry · 2026Article
- Repeated Cold Water Stress Leads to Improvements in Mitochondrial Metabolism of Skeletal Muscles in Rats.Metabolites · 2026Article
- Prevention and Treatment of Postsurgical Pain: Pharmacologic and Nonpharmacologic Interventions Across the Surgical Continuum.Clinics in geriatric medicine · 2026Review
- Thermal stress: an untapped potential in rehabilitation? An opinion paper on Finnish sauna and whole-body cryostimulation.Frontiers in rehabilitation sciences · 2026Review
- Cryotherapy reduces pain post-hemorrhoidectomy (CYPHER): a randomized, controlled, superiority trial of intra-anal ice after surgery for grade III hemorrhoids.Annals of coloproctology · 2025Article
- Complementary Approaches to Postoperative Pain Management: A Review of Non-pharmacological Interventions.Pain and therapy · 2025Review
- The impact of quadriceps release therapy on rehabilitation of adolescent athletes with Osgood-Schlatter disease: a retrospective cohort study.Orthopedic reviews · 2025Article
- The Effect of Therapeutic Exercise and Local Cryotherapy on Lower Limb Enthesitis in Non-Radiographic Axial Spondyloarthritis: A Case Report.Journal of personalized medicine · 2024Article
- Cold for centuries: a brief history of cryotherapies to improve health, injury and post-exercise recovery.European journal of applied physiology · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cold therapy has been used regularly as an immediate treatment to induce analgesia following acute soft-tissue injuries, however, a prolonged ice application has proved to delay the start of the healing and lengthen the recovery process. Hyperbaric gaseous cryotherapy, also known as neurocryostimulation, has shown the ability to overcome most of the limitations of traditional cold therapy, and meanwhile promotes the analgesic and anti-inflammatory effects well, but the current existing studies have shown conflicting results on its effects. Traditional cold therapy still has beneficial effect especially when injuries are severe and swelling is the limiting factor for recovery after soft-tissue injuries, and therefore no need to be entirely put out to pasture in the rehabilitation practice. Strong randomized controlled trials with good methodological quality are still needed in the future to evaluate the effects of different cryotherapy modalities.
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Registered trials
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