Evidence map›Paper›PMID 34141710›Full record

ArticleFrontiers in cell and developmental biology2021

Exosomal miR-2276-5p in Plasma Is a Potential Diagnostic and Prognostic Biomarker in Glioma.

Jingxian Sun, Zhenying Sun, Ilgiz Gareev, Tao Yan, Xin Chen, Aamir Ahmad, Daming Zhang, Boxian Zhao, Ozal Beylerli, Guang Yang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Jingxian SunDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhenying SunDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ilgiz GareevCentral Research Laboratory, Bashkir State Medical University, Ufa, Russia.
Tao YanDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xin ChenDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Aamir AhmadUniversity of Alabama at Birmingham, Birmingham, AL, United States.
Daming ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Boxian ZhaoDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ozal BeylerliCentral Research Laboratory, Bashkir State Medical University, Ufa, Russia.
Guang YangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Shiguang ZhaoDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
First Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNBashkir State Medical University · RUUniversity of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExosomal microRNAs (miRNAs) play an essential role in near and distant intercellular communication and are potential diagnostic and prognostic biomarkers for various cancers. This study focused on evaluation of exosomal miR-2276-5p in plasma as a diagnostic and prognostic biomarker for glioma.

methodsPlasma exosomes from 124 patients with glioma and 36 non-tumor controls were collected and subjected to quantitative real-time polymerase chain reaction (qRT-PCR) analysis for the exosomal miR-2276-5p expression. Bioinformatic analyses were performed to identify a gene target, and CGGA and TCGA databases were checked for evaluation of prognostic relevance.

resultsThe exosomal miR-2276-5p in glioma patients had a significantly decreased expression, compared with non-glioma patients (

conclusionThe circulating exosomal miR-2276-5p is significantly reduced in the plasma of glioma patients, and thus, it could be a potential biomarker for patients with glioma for diagnostic and/or prognostic purposes.

Indexed as

circulating exosomesgliomamiRNA-2276-5pprognosisRAB13

Identifiers

PMID34141710
PMCPMC8204016
OpenAlexW3171860450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.