Evidence map›Paper›PMID 34141562›Full record

ArticleBiomedical spectroscopy and imaging2020

The Potential of Utilizing Mid-Energy X-Rays for In-Line Phase Sensitive Breast Cancer Imaging.

F H Omoumi, M U Ghani, M D Wong, Y Li, B Zheng, A Yan, P A Jenkins, X Wu, H Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical spectroscopy and imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

F H OmoumiAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, The University of Oklahoma, Norman, OK 73019, U.S.A.
M U GhaniAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, The University of Oklahoma, Norman, OK 73019, U.S.A.
M D WongAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, The University of Oklahoma, Norman, OK 73019, U.S.A.
Y LiAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, The University of Oklahoma, Norman, OK 73019, U.S.A.
B ZhengAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, The University of Oklahoma, Norman, OK 73019, U.S.A.
A YanDepartment of Radiology, The University of Alabama at Birmingham, AL 35249, U.S.A.
P A JenkinsDepartment of Radiology and Imaging Science, The University of Utah School of Medicine, Salt Lake- City, UT 74132, U.S.A.
X WuDepartment of Radiology, The University of Alabama at Birmingham, AL 35249, U.S.A.
H LiuAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, The University of Oklahoma, Norman, OK 73019, U.S.A.
University of Oklahoma · USUniversity of Alabama at Birmingham · USUniversity of Utah · US

Funding

Clinical Translation of High Energy Phase-Sensitive X-ray Breast TomosynthesisR01CA193378 · NCI · UNIVERSITY OF OKLAHOMA · PI FAJARDO, LAURIE L, JING, ZHENXUE · 2015 to 2019
$3.0M
NCI NIH HHS R01 CA193378
6 · The paper itself

Abstract

objectiveThe objective of this study is to demonstrate the potential of utilizing mid-energy x-rays for in-line phase-sensitive breast cancer imaging by phantom studies.

methodsThe midenergy (50-80kV) in-line phase sensitive imaging prototype was used to acquire images of the contrast-detail mammography (CDMAM) phantom, an ACR accreditation phantom, and an acrylic edge phantom. The low-dose mid-energy phase-sensitive images were acquired at 60 kV with a radiation dose of 0.9 mGy, while the high-energy phase-sensitive images were acquired at 90 kV with a radiation dose of 1.2 mGy. The Phase-Attenuation Duality (PAD) principle for soft tissue was used for the phase retrieval. A blind observer study was conducted and paired-sample T-test were performed to compare the mean differences in the two imaging systems.

resultsThe correct detection ratio for the CDMAM phantom for phase-contrast images acquired by the low-dose mid-energy system was 56.91%, whereas images acquired by the high-energy system correctly revealed only 40.97% of discs. The correct detection ratios were 57.88% and 43.41% for phase-retrieved images acquired by the low-dose mid-energy and high-energy imaging systems, respectively. The reading scores for all three groups of objects in the ACR phantom were higher for the mid energy imaging system as compared to the high-energy system for both phase-contrast and phase- retrieved images. The calculated edge enhancement index (EEI) from the acrylic edge phantom image for the mid-energy system was higher than that calculated for the high-energy imaging system. The quantitative analyses showed a higher Contrast to Noise Ratio (CNR) as well as a higher Figure of Merit (FOM) in images acquired by the low-dose mid-energy imaging system.

conclusionThe PAD based retrieval method can be applied in mid-energy system without remarkably affecting the image quality, and in fact, it improves the lesion detectability with a patient dose saving of 25%.

Indexed as

Mid-energy phase-sensitive x-ray imagingphase-contrast x-ray imagingPhase retrieval

Identifiers

PMID34141562
PMCPMC8208526
OpenAlexW3036999191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.