Evidence map›Paper›PMID 34141455›Full record

ArticleImmunometabolism2021

The Metabolic Clock Model of B Cell Activation and Differentiation.

Munir Akkaya

Abstract read
In one paragraph

Article in Immunometabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. In the activation of HPV-specific human B cells HPV-VLP vaccines mimic membrane-associated antigens.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Munir AkkayaLaboratory of Immunogenetics, NIAID, NIH Rockville, MD 20852, USA.

Funding

Intracellular Trafficking Of The B-cell Antigen ReceptorZ01AI000899 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI PIERCE, SUSAN · 2001 to 2008
$625k
Intramural NIH HHS Z01 AI000899
6 · The paper itself

Abstract

Recent advancements in the field of B cell immunometabolism have provided mechanistic insights to B cell activation and fate determination. Here, in this short article, I will explain the main principles of our novel metabolic clock model and how it may reshape our perspective on longstanding immunological questions related to pathologies arising from out of context B cell activation.

Indexed as

B cellshumoral immunityperipheral tolerance

Identifiers

PMID34141455
PMCPMC8208592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.