Evidence map›Paper›PMID 34141160›Full record

ArticleToxicology research2021

Imidazolidinyl urea activates mast cells via MRGPRX2 to induce non-histaminergic allergy.

Jiapan Gao, Delu Che, Xueshan Du, Yi Zheng, Huiling Jing, Nan Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jiapan GaoDepartment of Pharmaceutical analysis, School of Pharmacy, Xi'an Jiaotong University, 76, Yanta west road, Xi'an, China.
Delu CheDepartment of Dermatology, Northwest Hospital, The Second Hospital Affiliated to Xi'an Jiaotong University, 157, Xiwu road, Xi'an, Shaanxi, China.
Xueshan DuDepartment of Dermatology, Northwest Hospital, The Second Hospital Affiliated to Xi'an Jiaotong University, 157, Xiwu road, Xi'an, Shaanxi, China.
Yi ZhengDepartment of Dermatology, Northwest Hospital, The Second Hospital Affiliated to Xi'an Jiaotong University, 157, Xiwu road, Xi'an, Shaanxi, China.
Huiling JingDepartment of Dermatology, Xi'an Hospital of Traditional Chinese Medicine, 69, Fengcheng 8th Road, Xi'an, Shaanxi, China.
Nan WangDepartment of Pharmaceutical analysis, School of Pharmacy, Xi'an Jiaotong University, 76, Yanta west road, Xi'an, China.
Second Affiliated Hospital of Xi'an Jiaotong University · CNXi'an Jiaotong University · CNShaanxi Provincial Hospital of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imidazolidinyl urea (IU) is used as an antimicrobial preservative in cosmetic and pharmaceutical products. IU induces allergic contact dermatitis, however, the mechanism has not yet been elucidated. Mas-related G protein-coupled receptor-X2 (MRGPRX2) triggers drug-induced pseudo-allergic reactions. The aims of this study were to determine whether IU activated mast cells through MRGPRX2 to further trigger contact dermatitis. Wild-type (WT) and Kit

Indexed as

contact dermatitisimidazolidinyl ureamast cellMRGPRX2tryptase

Identifiers

PMID34141160
PMCPMC8201555
OpenAlexW3157457180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.