Evidence map›Paper›PMID 34141131›Full record

ArticleComputational and structural biotechnology journal2021

Gut lactate-producing bacteria promote CD4 T cell recovery on Anti-retroviral therapy in HIV-infected patients.

Wei Lyu, Qingren Meng, Jingfa Xiao, Jing Li, Jian Wang, Zhifeng Qiu, Xiaojing Song, Hua Zhu, Changjun Shao, Yanan Chu and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Wei LyuDepartment of Infectious Disease, Peking Union Medical College Hospital, & Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Qingren MengCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, & China National Center for Bioinformation, Beijing 100101, China.
Jingfa XiaoCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, & China National Center for Bioinformation, Beijing 100101, China.
Jing LiDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.
Jian WangCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, & China National Center for Bioinformation, Beijing 100101, China.
Zhifeng QiuDepartment of Infectious Disease, Peking Union Medical College Hospital, & Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Xiaojing SongDepartment of Infectious Disease, Peking Union Medical College Hospital, & Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Hua ZhuInstitute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) Comparative Medical Center, Peking Union Medical College (PUMC), Beijing 100021, China.
Changjun ShaoCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, & China National Center for Bioinformation, Beijing 100101, China.
Yanan ChuCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, & China National Center for Bioinformation, Beijing 100101, China.
Qian ZhouCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People's Republic of China.
Taisheng LiDepartment of Infectious Disease, Peking Union Medical College Hospital, & Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Routy Jean-PierreChronic Viral Illnesses Service and Division of Hematology, McGill University Health Centre, Montreal, QC, Canada.
Jun YuCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, & China National Center for Bioinformation, Beijing 100101, China.
Yang HanDepartment of Infectious Disease, Peking Union Medical College Hospital, & Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Yu KangCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, & China National Center for Bioinformation, Beijing 100101, China.
Chinese Academy of Sciences · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNMcGill University Health Centre · CAPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-retroviral therapy (ART) effectively suppresses viral replication in HIV-infected patients, however CD4 + cell restoration to normal value is not achieved by 15-20% of patients who are called immune non-responders. Gut microbiota composition has been shown to influence host immunity. Herein, to identify intestinal microbial agents that may influence the CD4 recovery in HIV-infected patients, we utilized a "Quasi-paired cohort" method to analyze intestinal metagenome data from immunological responders (IRs) and immunological non-responders (INRs). This method identified significant enrichment for

Indexed as

HIVImmune recoveryLactic acid bacteriaMetagenome

Identifiers

PMID34141131
PMCPMC8191414
OpenAlexW3160658387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.