Evidence map›Paper›PMID 34141090›Full record

ArticleACS medicinal chemistry letters2021

Discovery of Arylsulfonamide Na

Anthony J Roecker, Mark E Layton, Joseph E Pero, Michael J Kelly, Thomas J Greshock, Richard L Kraus, Yuxing Li, Rebecca Klein, Michelle Clements, Christopher Daley and 10 more

Open access · greenAbstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Inhibition of NaRSC medicinal chemistry · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Anthony J RoeckerDiscovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.ORCID https://orcid.org/0000-0002-7688-7651
Mark E LaytonDiscovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Joseph E PeroDiscovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.ORCID https://orcid.org/0000-0003-2674-4713
Michael J KellyDiscovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Thomas J GreshockDiscovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.ORCID https://orcid.org/0000-0002-3313-9733
Richard L KrausPharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Yuxing LiPharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Rebecca KleinPharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Michelle ClementsPharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Christopher DaleyPharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Aneta JovanovskaPharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Jeanine E BallardPharmacokinetic, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Deping WangComputational and Structural Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Fuqiang ZhaoTranslational Imaging and Biomarkers, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Andrew P J BrunskillMolecular and Materials Characterization, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Xuanjia PengHitS Unite, WuXi AppTec Co., Ltd. (Shanghai), Shanghai 200131, China.ORCID https://orcid.org/0000-0001-6067-0311
Xiu WangIDSU, WuXi AppTec Co., Ltd. (Shanghai), Shanghai 200131, China.
Haiyan SunIDSU, WuXi AppTec Co., Ltd. (Shanghai), Shanghai 200131, China.
Andrea K HoughtonPharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Christopher S BurgeyDiscovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
United States Military Academy · USWuXi AppTec (China) · CNMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The voltage-gated sodium channel Na

Identifiers

PMID34141090
PMCPMC8201757
OpenAlexW3169581185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.