Evidence map›Paper›PMID 34140956›Full record

ReviewFrontiers in immunology2021

Vascular Endothelial Galectins in Leukocyte Trafficking.

Abbey Lightfoot, Helen M McGettrick, Asif J Iqbal

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Where the Action Is-Leukocyte Recruitment in Atherosclerosis.Frontiers in cardiovascular medicine · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Abbey LightfootInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom.
Helen M McGettrickInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
Asif J IqbalInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom.
University of Birmingham · GB

Funding

Medical Research Council MR/T028025/1Wellcome Trust 222392/Z/21/Z
6 · The paper itself

Abstract

Leukocyte recruitment to the site of injury is a crucial event in the regulation of an inflammatory response. Tight regulation of interactions between the endothelium and circulating leukocytes is necessary to ensure a protective response to injury does not result in inflammatory disease. Rising interest in the broad immunoregulatory roles displayed by members of the glycan-binding galectin family suggests that these proteins could be an attractive target for therapeutic intervention, since their expression is significantly altered in disease. The focus of this review is to summarize current knowledge on the role of galectins in leukocyte trafficking during inflammation and the clinical approaches being taken to target these interactions for treatment of inflammatory disease.

Indexed as

Cell AdhesionLeukocyte RollingAnimalsAnti-Inflammatory AgentsEndothelial CellsEndothelium, VascularGalectinsHumansInflammationLeukocytesSignal TransductionAnti-Inflammatory AgentsGalectinsendothelial cellgalectinsglycan-binding proteinleukocyte traffickingvascular biology

Identifiers

PMID34140956
PMCPMC8204101
OpenAlexW3167306413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.