Evidence map›Paper›PMID 34140955›Full record

ArticleFrontiers in immunology2021

Key Macrophage Responses to Infection With

Monika Looney, Rachel Lorenc, Marc K Halushka, Petros C Karakousis

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Epigenetic Reprogramming byAntibiotics (Basel, Switzerland) · 2026
    Review
  2. Macrophage states and polarization duringFrontiers in cellular and infection microbiology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Epigenetic Mechanisms Induced byInternational journal of molecular sciences · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. microLife · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Monika LooneyDepartment of Medicine, Division of Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Rachel LorencDepartment of Medicine, Division of Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Marc K HalushkaDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Petros C KarakousisDepartment of Medicine, Division of Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Statins as Adjunctive, Host-Directed Therapy for TBUH3AI122309 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C · 2017 to 2019
$4.3M
Foam cells as drug targets in tuberculosisR01HL149450 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI GENNARO, MARIA LAURA, KARAKOUSIS, PETROS C · 2019 to 2022
$3.9M
Mentoring in Immunometabolic Dysregulation in TB and TB/HIVK24AI143447 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C · 2019 to 2024
$956k
NHLBI NIH HHS R01 HL149450NIAID NIH HHS K24 AI143447NIAID NIH HHS UH3 AI122309
6 · The paper itself

Abstract

Tuberculosis (TB) is the leading cause of death from infection with a single bacterial pathogen. Host macrophages are the primary cell type infected with

Indexed as

DNA MethylationEpigenesis, GeneticFemaleGenome-Wide Association StudyHost-Pathogen InteractionsHumansMacrophagesMaleMicroRNAsMycobacterium tuberculosisSignal TransductionTuberculosisMicroRNAshost responsemacrophagesmethylationmicroRNAstuberculosis

Identifiers

PMID34140955
PMCPMC8204050
OpenAlexW3171581194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.