Evidence map›Paper›PMID 34140854›Full record

ArticleEngineering in life sciences2021

Cost-effective purification process development for chimeric hepatitis B core (HBc) virus-like particles assisted by molecular dynamic simulation.

Bingyang Zhang, Shuang Yin, Yingli Wang, Zhiguo Su, Jingxiu Bi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Engineering in life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bingyang ZhangSchool of Chemical Engineering & Advanced Materials, Faculty of Engineering, Computer and Mathematical Sciences University of Adelaide Adelaide SA Australia.
Shuang YinSchool of Chemical Engineering & Advanced Materials, Faculty of Engineering, Computer and Mathematical Sciences University of Adelaide Adelaide SA Australia.
Yingli WangSchool of Chinese Medicine and Food Engineering Shanxi University of Traditional Chinese Medicine Jinzhong Shanxi Province P. R. China.
Zhiguo SuState Key Laboratory of Biochemical Engineering, Institute of Process Engineering Chinese Academy of Sciences Beijing P. R. China.
Jingxiu BiSchool of Chemical Engineering & Advanced Materials, Faculty of Engineering, Computer and Mathematical Sciences University of Adelaide Adelaide SA Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inserting foreign epitopes to hepatitis B core (HBc) virus-like particles (VLPs) could influence the molecular conformation and therefore vary the purification process. In this study, a cost-effective purification process was developed for two chimeric HBc VLPs displaying Epstein-Barr nuclear antigens 1 (EBNA1), and hepatitis C virus (HCV) core. Both chimeric VLPs were expressed in soluble form with high production yields in

Indexed as

hepatitis B coremolecular dynamic simulationprotein characterizationprotein purificationvirus‐like particle

Identifiers

PMID34140854
PMCPMC8182290

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.