ArticleBiochemia medica2021
Performance of D-dimer for predicting sepsis mortality in the intensive care unit.
Article in Biochemia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The association between coagulation function and prognosis in patients with sepsis: a meta-analysis of predictive performance introduction.Frontiers in medicine · 2025Pooled it
- A Systematic Review of Predictor Composition, Outcomes, Risk of Bias, and Validation of COVID-19 Prognostic Scores.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Pooled it
- Short- and long-term risk stratification in acutely ill medical patients by implementing D-dimer in the emergency setting - A prospective cohort study.American heart journal plus : cardiology research and practice · 2026Article
- The Prognostic Value of Cardiac Biomarkers in Combination with the SOFA Score for the Evaluation of Sepsis-Related Mortality.Medicina (Kaunas, Lithuania) · 2026Article
- Elevated D-dimer is independently associated with in-hospital mortality in patients withFrontiers in cellular and infection microbiology · 2026Article
- Diagnostic and prognostic utility of D-dimer and heparin-binding protein in neonatal sepsis: A prospective case-control study.World journal of clinical pediatrics · 2025Article
- Prognostic value of baseline plasma D-dimer levels in sepsis: a prospective cohort study.Practical laboratory medicine · 2025Article
- Prognostic risk factors in upper gastrointestinal perforation: the role of body composition parameters.Frontiers in nutrition · 2025Article
- Association between D-dimer-to-albumin ratio and 28-days all-cause mortality in patients with sepsis.Scientific reports · 2024Article
- Article
- D-dimer as a Useful Biomarker in Early Diagnosis of Neonatal Sepsis: A Single-Center Study From Romania.Cureus · 2024Article
- Fibrinogen contribution to clot strength in patients with sepsis and hematologic malignancies and thrombocytopenia-a prospective, single-center, analytical, cross-sectional study.Research and practice in thrombosis and haemostasis · 2024Article
- Association between D-dimer to lymphocyte ratio and in hospital all-cause mortality in elderly patients with sepsis: a cohort of 1123 patients.Frontiers in cellular and infection microbiology · 2024Article
- The relationship between hemoglobin/red blood cell distribution width ratio and mortality in patients with intracranial hemorrhage: a possible protective effect for the elderly?Internal and emergency medicine · 2023Article
- A Global Assessment of Coagulation Profile and a Novel Insight into Adamts-13 Implication in Neonatal Sepsis.Biology · 2023Article
- Coagulation Disorders in Sepsis and COVID-19-Two Sides of the Same Coin? A Review of Inflammation-Coagulation Crosstalk in Bacterial Sepsis and COVID-19.Journal of clinical medicine · 2023Review
- Article
- Prognostic value of PaOThe Journal of international medical research · 2022Article
- Hematologic System Dysregulation in Critically Ill Septic Patients with Anemia-A Retrospective Cohort Study.International journal of environmental research and public health · 2022Observational
- Elevated plasma D-dimer levels are associated with the poor prognosis of critically ill children.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe prognostic value of D-dimer (DD) in sepsis remains controversial. This study aimed to investigate the performance of DD for predicting sepsis mortality in the hospital and for identifying its potential correlates. MATERIALS AND
methodsThe clinical and laboratory data of adult sepsis patients were extracted from the Medical Information Mart for Intensive Care III (MIMIC III, v1.4) database using the structured query language (SQL). The database contains critical illness admitted to the intensive care unit at Beth Israel Deaconess Medical Center between June 2001 and October 2012. The association between DD and mortality was investigated with receiver operating characteristic (ROC) curve, restricted cubic spline and logistic regression analysis. Subgroup analysis was also used for identifying DD correlates.
resultsThe study population consisted of 358 sepsis patients. Those who died during hospital stay (N = 160) had significantly higher DD values than those who survived (N = 198). The area under the ROC curve (AUC) of DD was 0.59 (P < 0.010). In subgroup analysis, white blood cell (WBC) count > 18 x10 DISCUSSION: We conclude that the accuracy of DD for predicting in-hospital sepsis mortality depends on WBC count and vasopressor therapy. Both low and extremely elevated DD values are associated with higher risk of death.
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