ArticleNature metabolism2021
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions.
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In one paragraph
Article in Nature metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 70 citations in OpenAlex.
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- Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues.American journal of human genetics · 2026Article
- Article
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- Computationally unmasking each fatty acyl C=C position in complex lipids by routine LC-MS/MS lipidomics.Nature communications · 2025Article
- Long-chain PUFA and painful temporomandibular disorder in the Hispanic Community Health Study/Study of Latinos.Public health nutrition · 2025Article
- Metabolomics in Pathogenic Pathways and Targeted Therapies for Diabetic Neuropathy: A Comprehensive Review.Metabolites · 2025Review
- The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi.Chemical reviews · 2025Review
- Physiotherapy Reduces Pain and Alters Fatty Acid Biomarkers in Women with Chronic Non-Specific Low Back Pain.International journal of women's health · 2025Article
- Anti-Aging Effect of Traditional Plant-Based Food: An Overview.Foods (Basel, Switzerland) · 2024Review
- The influence of sex on neuroimmune communication, pain, and physiology.Biology of sex differences · 2024Review
- The Impact of Nutrition on Pain: A Narrative Review of Recent Literature.Current pain and headache reports · 2024Review
- Protein phosphatase 2Cm-regulated branched-chain amino acid catabolic defect in dorsal root ganglion neurons drives pain sensitization.Acta neuropathologica communications · 2024Article
- Nutritional Strategies for Chronic Craniofacial Pain and Temporomandibular Disorders: Current Clinical and Preclinical Insights.Nutrients · 2024Review
- Chronic Overlapping Pain Conditions and Nociplastic Pain.medRxiv : the preprint server for health sciences · 2024Article
- Association of Serum Unsaturated Fatty Acid Patterns with the Risk of Diabetic Nephropathy.Kidney diseases (Basel, Switzerland) · 2024Article
- Editorial: Diet, nutrition, and functional foods for chronic pain.Frontiers in nutrition · 2024Article
- Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets.Scientific reports · 2023Article
- Associations of tissue damage induced inflammatory plasticity in masseter muscle with the resolution of chronic myalgia.Scientific reports · 2023Article
- Binding interactions of fatty acyl lipid mediators within the vanilloid pocket of TRPV1: A molecular dynamics study.Prostaglandins & other lipid mediators · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 1 country.
Jacob T Boyd *Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Peter M LoCoco *Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Ashley R FurrDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Michelle R BendeleDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Meilinn TramDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Qun LiDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Fang-Mei ChangDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Madeline E ColleyDepartment of Chemistry, University of Texas San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-9515-3493
Grace M SamenukDepartment of Chemistry, University of Texas San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-5527-0281
Dominic A ArrisDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-8265-3133
Erin E LockeDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Stephan B H BachDepartment of Chemistry, University of Texas San Antonio, San Antonio, TX, USA.
Alejandro TobonDepartment of Neurology, South Texas Veterans Health Care System, San Antonio, TX, USA.
Shivani B RuparelDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Kenneth M HargreavesDepartment of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. hargreaves@uthscsa.edu.ORCID http://orcid.org/0000-0002-1076-4931
The University of Texas Health Science Center at San Antonio · USThe University of Texas at San Antonio · USSouth Texas Veterans Health Care System · US
Funding
NORTH AND CENTRAL TEXAS CTSA FOR PEDIATRIC RESEARCHUL1RR024982 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2007 to 2011
$27.9MInstitute for Integration of Medicine & Science: A Partnership to Improve HealthUM1TR004538 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ROBERT A CLARK, Kenneth M Hargreaves · 2023 to 2026
$22.3MInstitute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR002645 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2018 to 2022
$20.4MInstitutional Research Training GrantT32DE014318 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Kenneth M Hargreaves · 2002 to 2026
$12.1MMechanisms for Omega-6 Modulation of Primary Afferent NociceptorsR01NS110948 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HARGREAVES, KENNETH M · 2019 to 2023
$1.7MMonoclonal Sandwich ELISA for Serum Erythroferrone for Clinical Assessment of Ineffective ErythropoiesisR44DK113841 · NIDDK · INTRINSIC LIFESCIENCES, LLC · PI OSTLAND, VAUGHN E · 2017 to 2018
$1.5MSouth Texas Medical Scientist Training Program (STX-MSTP)T32GM113896 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CAVAZOS, JOSE E · 2018 to 2022
$1.1MA novel approach to study pain in a mouse model of facial burn injuryF30DE028486 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI WALLACE, ASHLEY R. · 2018 to 2022
$206kRole of High Omega-6 Diet as a Risk Factor for Pain Through Increased TRPV1 and TRPA1 ActivityF30AT009949 · NCCIH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BOYD, JACOB TYLER · 2018 to 2020
$100kRole of Oxidized Omega-6 Fatty Acid Metabolites in Diabetic NeuropathyF32DK118841 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LOCOCO, PETER MANNING · 2019 to 2019
$62kNCATS NIH HHS UL1 TR002645NCATS NIH HHS UM1 TR004538NCCIH NIH HHS F30 AT009949NCRR NIH HHS UL1 RR024982NIDCR NIH HHS F30 DE028486NIDCR NIH HHS T32 DE014318NIDDK NIH HHS F32 DK118841NIDDK NIH HHS R44 DK113841NIGMS NIH HHS T32 GM113896NINDS NIH HHS R01 NS110948
Abstract
Chronic pain is the leading cause of disability worldwide
Indexed as
BiomarkersDisease SusceptibilityAnimalsChronic PainDietDisease Models, AnimalFatty Acids, Omega-6Fatty Acids, UnsaturatedGanglia, SpinalLipid MetabolismMicePeripheral Nervous System DiseasesPhospholipases A2Risk FactorsBiomarkersFatty Acids, Omega-6Fatty Acids, UnsaturatedPhospholipases A2
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.