Evidence map›Paper›PMID 34140679›Full record

ReviewNature immunology2021

Not-so-opposite ends of the spectrum: CD8

Jenna L Collier, Sarah A Weiss, Kristen E Pauken, Debattama R Sen, Arlene H Sharpe

Open access · bronzeAbstract readReview
In one paragraph

Review in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 1 synthesis or guideline pooled it, 222 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Protein-dependent CD4iScience · 2026
    Article
  7. Review
  8. DADA Enhances CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Diagnostics (Basel, Switzerland) · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. CD8Frontiers in immunology · 2026
    Review
  18. Article
  19. Review
  20. Article

100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jenna L Collier *Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4071-4986
Sarah A Weiss *Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4155-0346
Kristen E PaukenDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4309-7880
Debattama R SenDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Arlene H SharpeDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Arlene_Sharpe@hms.harvard.edu.ORCID http://orcid.org/0000-0002-9736-2109
Brigham and Women's Hospital · USBroad Institute · USHarvard University · US

Funding

Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI David A. Hafler · 1996 to 2026
$51.7M
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5M
Synergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Dario AA Vignali · 2015 to 2026
$30.8M
NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI056299NIAID NIH HHS P01 AI108545NIGMS NIH HHS T32 GM007753
6 · The paper itself

Abstract

CD8

Indexed as

AutoimmunityAnimalsAutoimmune DiseasesB7-H1 AntigenCD8-Positive T-LymphocytesChronic DiseaseCommunicable DiseasesCytokinesEpigenesis, GeneticHumansImmune Checkpoint InhibitorsLymphocytes, Tumor-InfiltratingNeoplasmsPhenotypeProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellB7-H1 AntigenCytokinesImmune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-Cell

Identifiers

PMID34140679
PMCPMC9197228
OpenAlexW3169670703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.