Evidence map›Paper›PMID 34140663›Full record

SynthesisHypertension research : official journal of the Japanese Society of Hypertension2021

Isometric handgrip exercise training reduces resting systolic blood pressure but does not interfere with diastolic blood pressure and heart rate variability in hypertensive subjects: a systematic review and meta-analysis of randomized clinical trials.

João Pedro Arantes de Sousa Almeida, Murilo Bessa, Leandro Teixeira Paranhos Lopes, Alexandre Gonçalves, Leonardo Roever, Hugo Ribeiro Zanetti

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Hypertension research : official journal of the Japanese Society of Hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Effects of dynamic, isometric and combined resistance training on blood pressure and its mechanisms in hypertensive men.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Trial
  6. Isometric Handgrip Training and Cardiovascular Risk Modulation: State of the Art.Journal of cardiovascular development and disease · 2026
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

João Pedro Arantes de Sousa AlmeidaDepartment of Medicine, IMEPAC University Center, Araguari, MG, Brazil.
Murilo BessaDepartment of Medicine, IMEPAC University Center, Araguari, MG, Brazil.
Leandro Teixeira Paranhos LopesDepartment of Medicine, Brazil University, Fernandópolis, SP, Brazil.
Alexandre GonçalvesDepartment of Medicine, IMEPAC University Center, Araguari, MG, Brazil.
Leonardo RoeverDepartment of Clinical Research, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Hugo Ribeiro ZanettiDepartment of Physical Education and Department of Medicine, IMEPAC University Center, Araguari, MG, Brazil. hugo.zanetti@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the effects of isometric handgrip exercise training (IHET) on blood pressure and heart rate variability in hypertensive subjects. Five databases were searched for randomized clinical trials in English, Spanish, or Portuguese evaluating the effect of IHET vs. no exercise on blood pressure (systolic and/or diastolic) and/or heart rate variability (low frequency [LF], high frequency [HF], and/or LF/HF ratio) through December 2020. Random-effects meta-analyses of mean differences (MDs) and/or standardized mean differences (SMDs) with 95% confidence intervals (CIs) were performed. Five trials were selected (n = 324 hypertensive subjects), whose durations ranged from 8 to 10 weeks. Compared to no exercise, IHET reduced systolic blood pressure (MD -8.11 mmHg, 95% CI -11.7 to -4.53, p < 0.001) but did not affect diastolic blood pressure (MD -2.75 mmHg, 95% CI -9.47-3.96, p = 0.42), LF (SMD -0.14, 95% CI -0.65-0.37, p = 0.59), HF (SMD 0.38, 95% CI -0.14-0.89, p = 0.15), or the LF/HF ratio (SMD -0.22, 95% CI -0.95-0.52, p = 0.57). IHET performed for 8-10 weeks had a positive effect on resting systolic blood pressure but did not interfere with diastolic blood pressure or heart rate variability in hypertensive subjects. These data should be interpreted with caution since all volunteers included in the studies were clinically medicated and their blood pressure was controlled.

Indexed as

Hand StrengthHypertensionBlood PressureExerciseHeart RateHumansRandomized Controlled Trials as TopicBlood pressureHeart rate variabilityHypertensionIsometric exercise

Identifiers

PMID34140663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.