ArticleCommunications biology2021
Dissecting the midlife crisis: disentangling social, personality and demographic determinants in social brain anatomy.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Meta-analyses of personality change from the preclinical to the clinical stages of dementia.Ageing research reviews · 2025Pooled it
- Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline.npj aging · 2025Article
- Development and validation of the concise midlife crisis measure.Scientific reports · 2025Article
- Pain can't be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design.BMC medicine · 2024Article
- Using rare genetic mutations to revisit structural brain asymmetry.Nature communications · 2024Article
- Mode-based morphometry: A multiscale approach to mapping human neuroanatomy.Human brain mapping · 2024Article
- Investigating the relationships between motor skills, cognitive status, and area deprivation index in Arizona: a pilot study.Frontiers in public health · 2024Article
- Bayesian modelling disentangles language versus executive control disruption in stroke.Brain communications · 2024Article
- Social enrichment on the job: Complex work with people improves episodic memory, promotes brain reserve, and reduces the risk of dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- The need to change: Is there a critical role of midlife adaptation in mental health later in life?eLife · 2023Review
- Bayesian stroke modeling details sex biases in the white matter substrates of aphasia.Communications biology · 2023Article
- Mode-based morphometry: A multiscale approach to mapping human neuroanatomy.bioRxiv : the preprint server for biology · 2023Article
- Interpersonal coordination in schizophrenia: a concise update on paradigms, computations, and neuroimaging findings.Psychoradiology · 2023Review
- Age differences in functional brain networks associated with loneliness and empathy.Network neuroscience (Cambridge, Mass.) · 2023Article
- The association between social engagement and depressive symptoms in middle-aged and elderly Chinese: A longitudinal subgroup identification analysis under causal inference frame.Frontiers in aging neuroscience · 2022Article
- Loneliness is linked to specific subregional alterations in hippocampus-default network covariation.Journal of neurophysiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
In any stage of life, humans crave connection with other people. In midlife, transitions in social networks can relate to new leadership roles at work or becoming a caregiver for aging parents. Previous neuroimaging studies have pinpointed the medial prefrontal cortex (mPFC) to undergo structural remodelling during midlife. Social behavior, personality predisposition, and demographic profile all have intimate links to the mPFC according in largely disconnected literatures. Here, we explicitly estimated their unique associations with brain structure using a fully Bayesian framework. We weighed against each other a rich collection of 40 UK Biobank traits with their interindividual variation in social brain morphology in ~10,000 middle-aged participants. Household size and daily routines showed several of the largest effects in explaining variation in social brain regions. We also revealed male-biased effects in the dorsal mPFC and amygdala for job income, and a female-biased effect in the ventral mPFC for health satisfaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.