ArticleNPJ biofilms and microbiomes2021
Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation.
Article in NPJ biofilms and microbiomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Advances in BODIPY Derivatives for Antibacterial Phototherapy.Angewandte Chemie (International ed. in English) · 2026Review
- Extracellular matrix chemistry tunes bacterial biofilm metabolism and optimizes fitness.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Operando Microscopy of Photosynthetic Microbial Biohybrids Using Fluorescent Chemical Probes.ACS electrochemistry · 2026Article
- Investigating Salmonella biofilm responses to antibiotic treatment using optical photothermal infrared spectroscopy.Communications biology · 2026Article
- Berberine Interferes with the Molecular Landscape of Biofilm-Driven Pathogenicity.Pathogens (Basel, Switzerland) · 2026Review
- Interactions Between Active Matters and Endogenous Fields.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Extracellular matrix chemistry tunes bacterial biofilm metabolism and optimizes fitness.bioRxiv : the preprint server for biology · 2025Article
- Electrochemical Control with High Spatiotemporal Resolutions for Extracellular pH Microenvironment.ACS electrochemistry · 2025Article
- Editorial for the Special Issue on Micro- and Nanosensors: Fabrication, Applications, and Performance Enhancements, 2nd Edition.Micromachines · 2025Article
- Recent Advancements and Applications of Nanosensors in Oral Health: Revolutionizing Diagnosis and Treatment.European journal of dentistry · 2025Article
- Long-term continuous corrosion of 316L stainless steel byFrontiers in bioengineering and biotechnology · 2025Article
- Mass transfer in heterogeneous biofilms: Key issues in biofilm reactors and AI-driven performance prediction.Environmental science and ecotechnology · 2024Review
- Effects of glucose and lactate onMicrobiology spectrum · 2024Article
- Development of a Novel, Ecologically Friendly Generation of pH-Responsive Alginate Nanosensors: Synthesis, Calibration, and Characterisation.Sensors (Basel, Switzerland) · 2023Article
- Innovations in the Design and Application of Stimuli-Responsive Restorative Dental Polymers.Polymers · 2023Review
- Diffusiophoretic Particle Penetration into Bacterial Biofilms.ACS applied materials & interfaces · 2023Article
- Illuminating the oral microbiome and its host interactions: tools and approaches for molecular ecological studies.FEMS microbiology reviews · 2023Review
- ROS generating BODIPY loaded nanoparticles for photodynamic eradication of biofilms.Frontiers in microbiology · 2023Article
- Supporting the strategic pillars of translational research in biofilms.NPJ biofilms and microbiomes · 2022Article
- On the Use of Polymer-Based Composites for the Creation of Optical Sensors: A Review.Polymers · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Understanding the dynamic environmental microniches of biofilms will permit us to detect, manage and exploit these communities. The components and architecture of biofilms have been interrogated in depth; however, little is known about the environmental microniches present. This is primarily because of the absence of tools with the required measurement sensitivity and resolution to detect these changes. We describe the application of ratiometric fluorescent pH-sensitive nanosensors, as a tool, to observe physiological pH changes in biofilms in real time. Nanosensors comprised two pH-sensitive fluorophores covalently encapsulated with a reference pH-insensitive fluorophore in an inert polyacrylamide nanoparticle matrix. The nanosensors were used to analyse the real-time three-dimensional pH variation for two model biofilm formers: (i) opportunistic pathogen Pseudomonas aeruginosa and (ii) oral pathogen Streptococcus mutans. The detection of sugar metabolism in real time by nanosensors provides a potential application to identify therapeutic solutions to improve oral health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.