Evidence map›Paper›PMID 34140492›Full record

ArticleNature communications2021

Mesoscale structure development reveals when a silkworm silk is spun.

Quan Wan, Mei Yang, Jiaqi Hu, Fang Lei, Yajun Shuai, Jie Wang, Chris Holland, Cornelia Rodenburg, Mingying Yang

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Microcompartmentalization Controls Silk Feedstock Rheology.Langmuir : the ACS journal of surfaces and colloids · 2023
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Quan WanCollege of Animal Science, Zhejiang University, Hangzhou, China.
Mei YangCollege of Animal Science, Zhejiang University, Hangzhou, China.
Jiaqi HuCollege of Animal Science, Zhejiang University, Hangzhou, China.
Fang LeiCollege of Animal Science, Zhejiang University, Hangzhou, China.
Yajun ShuaiCollege of Animal Science, Zhejiang University, Hangzhou, China.ORCID 0000-0003-3313-1800
Jie WangCollege of Animal Science, Zhejiang University, Hangzhou, China.
Chris HollandDepartment of Material Science and Engineering, University of Sheffield, Sheffield, UK. christopher.holland@sheffield.ac.uk.ORCID 0000-0003-0913-2221
Cornelia RodenburgDepartment of Material Science and Engineering, University of Sheffield, Sheffield, UK. c.rodenburg@sheffield.ac.uk.ORCID 0000-0002-9590-375X
Mingying YangCollege of Animal Science, Zhejiang University, Hangzhou, China. yangm@zju.edu.cn.ORCID 0000-0003-1256-6514

Funding

Investigation of metabolites related to manganese exposureF31ES027304 · NIEHS · UNIVERSITY OF WASHINGTON · PI BAKER, MARISSA GAYL · 2016 to 2017
$61k
NIEHS NIH HHS 27304C2054
6 · The paper itself

Abstract

Silk fibre mechanical properties are attributed to the development of a multi-scale hierarchical structure during spinning. By careful ex vivo processing of a B. mori silkworm silk solution we arrest the spinning process, freezing-in mesoscale structures corresponding to three distinctive structure development stages; gelation, fibrilization and the consolidation phase identified in this work, a process highlighted by the emergence and extinction of 'water pockets'. These transient water pockets are a manifestation of the interplay between protein dehydration, phase separation and nanofibril assembly, with their removal due to nanofibril coalescence during consolidation. We modeled and validated how post-draw improves mechanical properties and refines a silk's hierarchical structure as a result of consolidation. These insights enable a better understanding of the sequence of events that occur during spinning, ultimately leading us to propose a robust definition of when a silkworm silk is actually 'spun'.

Indexed as

AnimalsBombyxFibroinsMicroscopy, Electron, ScanningPorosityProtein Conformation, beta-StrandSilkSpectrum Analysis, RamanWaterFibroinsSilkWater

Identifiers

PMID34140492
PMCPMC8211695

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.