Evidence map›Paper›PMID 34140475›Full record

ArticleNature communications2021

Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging.

Bongjoong Kim, Arvin H Soepriatna, Woohyun Park, Haesoo Moon, Abigail Cox, Jianchao Zhao, Nevin S Gupta, Chi Hoon Park, Kyunghun Kim, Yale Jeon and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Stretchable large-area transparent nanowire composite arrays for label-free multimodal interrogation of cardiac physiology.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Nanomaterial-Based Inkjet Printing for Electrochemical Sensing.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Bongjoong Kim *School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Arvin H Soepriatna *Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-7756-1389
Woohyun ParkSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-1799-3104
Haesoo MoonWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Abigail CoxDepartment of Comparative Pathobiology, Purdue College of Veterinary Medicine, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0003-2262-8168
Jianchao ZhaoChemical Diagnostics and Engineering, Los Alamos National Laboratory, Los Alamos, NM, USA.
Nevin S GuptaChemical Diagnostics and Engineering, Los Alamos National Laboratory, Los Alamos, NM, USA.
Chi Hoon ParkChemical Diagnostics and Engineering, Los Alamos National Laboratory, Los Alamos, NM, USA.
Kyunghun KimWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Yale JeonWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Hanmin JangWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-7724-4244
Dong Rip KimSchool of Mechanical Engineering, Hanyang University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-6398-9483
Hyowon LeeWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0001-7628-1441
Kwan-Soo LeeChemical Diagnostics and Engineering, Los Alamos National Laboratory, Los Alamos, NM, USA. kslee@lanl.gov.ORCID http://orcid.org/0000-0002-5315-3487
Craig J GoergenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. cgoergen@purdue.edu.ORCID http://orcid.org/0000-0001-8883-7953
Chi Hwan LeeSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA. lee2270@purdue.edu.ORCID http://orcid.org/0000-0002-4868-7054

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing need for the implementation of stretchable biosensors in the body has driven rapid prototyping schemes through the direct ink writing of multidimensional functional architectures. Recent approaches employ biocompatible inks that are dispensable through an automated nozzle injection system. However, their application in medical practices remains challenged in reliable recording due to their viscoelastic nature that yields mechanical and electrical hysteresis under periodic large strains. Herein, we report sponge-like poroelastic silicone composites adaptable for high-precision direct writing of custom-designed stretchable biosensors, which are soft and insensitive to strains. Their unique structural properties yield a robust coupling to living tissues, enabling high-fidelity recording of spatiotemporal electrophysiological activity and real-time ultrasound imaging for visual feedback. In vivo evaluations of custom-fit biosensors in a murine acute myocardial infarction model demonstrate a potential clinical utility in the simultaneous intraoperative recording and imaging on the epicardium, which may guide definitive surgical treatments.

Indexed as

AnimalsBiocompatible MaterialsBiosensing TechniquesCell LineDiagnostic ImagingDisease Models, AnimalElectrocardiographyElectrophysiological PhenomenaImage Processing, Computer-AssistedInkMaleMiceMice, Inbred C57BLMolecular Dynamics SimulationMyoblastsMyocardial InfarctionBiocompatible MaterialsSilicones

Identifiers

PMID34140475
PMCPMC8211747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.