Evidence map›Paper›PMID 34140474›Full record

ArticleNature communications2021

A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription.

Long Jin, Qianzi Tang, Silu Hu, Zhongxu Chen, Xuming Zhou, Bo Zeng, Yuhao Wang, Mengnan He, Yan Li, Lixuan Gui and 18 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 139 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 7 institutions in 2 countries.

Long Jin *Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.ORCID 0000-0002-6055-4692
Qianzi Tang *Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China. tangqianzi@sicau.edu.cn.ORCID 0000-0003-3235-3372
Silu Hu *Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Zhongxu Chen *Department of Life Science, Tcuni Inc., Chengdu, Sichuan, China.
Xuming Zhou *Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Bo ZengInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Yuhao WangInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Mengnan HeInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Yan LiInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Lixuan GuiDepartment of Life Science, Tcuni Inc., Chengdu, Sichuan, China.
Linyuan ShenInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Keren LongInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Jideng MaInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Xun WangInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Zhengli ChenKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Yanzhi JiangCollege of Life Science, Sichuan Agricultural University, Ya'an, Sichuan, China.
Guoqing TangInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Li ZhuInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Fei LiuInformation and Educational Technology Center, Sichuan Agricultural University, Chengdu, Sichuan, China.
Bo ZhangYa'an Digital Economy Operation Company, Ya'an, Sichuan, China.
Zhiqing HuangInstitute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, China.ORCID 0000-0001-5092-9297
Guisen LiRenal Department and Nephrology Institute, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.ORCID 0000-0003-1970-9979
Diyan LiInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.ORCID 0000-0001-7490-3550
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-0372-7016
Jingdong YinState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Yiren GuAnimal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, Chengdu, Sichuan, China.
Xuewei LiInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China.
Mingzhou LiInstitute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, China. mingzhou.li@sicau.edu.cn.ORCID 0000-0001-8681-7684
Sichuan Agricultural University · CNBrigham and Women's Hospital · USChina Agricultural University · CNChinese Academy of Sciences · CNFourth People's Hospital of Sichuan Province · CNSichuan Animal Science Academy · CNYa'an Polytechnic College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A comprehensive transcriptomic survey of pigs can provide a mechanistic understanding of tissue specialization processes underlying economically valuable traits and accelerate their use as a biomedical model. Here we characterize four transcript types (lncRNAs, TUCPs, miRNAs, and circRNAs) and protein-coding genes in 31 adult pig tissues and two cell lines. We uncover the transcriptomic variability among 47 skeletal muscles, and six adipose depots linked to their different origins, metabolism, cell composition, physical activity, and mitochondrial pathways. We perform comparative analysis of the transcriptomes of seven tissues from pigs and nine other vertebrates to reveal that evolutionary divergence in transcription potentially contributes to lineage-specific biology. Long-range promoter-enhancer interaction analysis in subcutaneous adipose tissues across species suggests evolutionarily stable transcription patterns likely attributable to redundant enhancers buffering gene expression patterns against perturbations, thereby conferring robustness during speciation. This study can facilitate adoption of the pig as a biomedical model for human biology and disease and uncovers the molecular bases of valuable traits.

Indexed as

Adipose TissueAlternative SplicingAnimalsBiological EvolutionCell LineCell LineageCell NucleusEnhancer Elements, GeneticEvolution, MolecularGene Expression ProfilingGene Regulatory NetworksMicroRNAsMitochondriaMolecular ConformationMuscle, SkeletalMyofibrilsMicroRNAsRNA, CircularRNA, Long NoncodingRNA, Messenger

Identifiers

PMID34140474
PMCPMC8211698
OpenAlexW3167292473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.