Evidence map›Paper›PMID 34140426›Full record

ArticleMolecules and cells2021

The FMRFamide Neuropeptide FLP-20 Acts as a Systemic Signal for Starvation Responses in

Chanhee Kang, Leon Avery

Open access · diamondAbstract read
In one paragraph

Article in Molecules and cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Application ofInternational journal of molecular sciences · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Chanhee KangSchool of Biological Sciences, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0003-4350-5706
Leon AveryDepartment of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID https://orcid.org/0000-0001-5548-3044
Seoul National University · KRSouthwestern Medical Center · US

Funding

Genetics of nematode pharyngeal muscle excitabilityR37HL046154 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI AVERY, LEON · 2004 to 2013
$2.8M
GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITYR01HL046154 · NHLBI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI AVERY, LEON · 1991 to 2003
$957k
NHLBI NIH HHS R01 HL046154NHLBI NIH HHS R37 HL046154
6 · The paper itself

Abstract

Most animals face frequent periods of starvation throughout their entire life and thus need to appropriately adjust their behavior and metabolism during starvation for their survival. Such adaptive responses are regulated by a complex set of systemic signals, including hormones and neuropeptides. While much progress has been made in identifying pathways that regulate nutrient-excessive states, it is still incompletely understood how animals systemically signal their nutrient-deficient states. Here, we showed that the FMRFamide neuropeptide FLP-20 modulates a systemic starvation response in

Indexed as

AnimalsCaenorhabditis elegansFMRFamideNeuropeptidesFMRFamideNeuropeptidesautophagymetabotropic glutamate receptorneuropeptidenutrient-deficient statesreceptor-type guanylate cyclasestarvation responsesystemic regulation

Identifiers

PMID34140426
PMCPMC8334353
OpenAlexW3172377586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.