Evidence map›Paper›PMID 34140410›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin.

Jingzhu Zhang, Adi Cohen, Bo Shen, Liming Du, Alpaslan Tasdogan, Zhiyu Zhao, Elizabeth J Shane, Sean J Morrison

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Bone matrix proteins: regulators of skeletal remodeling and repair.Journal of bone and mineral metabolism · 2026
    Review
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  8. Deep imaging of LepRBone research · 2025
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  9. Article
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  11. Article
  12. Review
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  15. Article
  16. Osteolectin increases bone elongation and body length by promoting growth plate chondrocyte proliferation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jingzhu ZhangChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235.ORCID 0000-0001-8811-1319
Adi CohenDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032.
Bo ShenChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235.
Liming DuChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235.
Alpaslan TasdoganChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235.
Zhiyu ZhaoChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235.
Elizabeth J ShaneDepartment of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032.
Sean J MorrisonChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235; sean.morrison@utsouthwestern.edu.ORCID 0000-0003-1587-8329
The University of Texas Southwestern Medical Center · USColumbia University · US

Funding

IDIOPATHIC OSTEOPOROSIS IN PREMENOPAUSAL WOMENR01AR049896 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHANE, ELIZABETH J · 2005 to 2009
$2.8M
Idiopathic Osteoporosis in Premenopausal WomenK24AR052665 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHANE, ELIZABETH J · 2005 to 2014
$1.8M
Characterization of a new growth factor from a bone marrow vascular nicheF32HL139016 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHEN, BO · 2017 to 2019
$179k
NHLBI NIH HHS F32 HL139016NIAMS NIH HHS K24 AR052665NIAMS NIH HHS R01 AR049896
6 · The paper itself

Abstract

We previously described a new osteogenic growth factor, osteolectin/Clec11a, which is required for the maintenance of skeletal bone mass during adulthood. Osteolectin binds to Integrin α11 (Itga11), promoting Wnt pathway activation and osteogenic differentiation by leptin receptor

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCancellous BoneFemaleHematopoietic Cell Growth FactorsHumansLectins, C-TypeMiceMice, Inbred C57BLOrgan SizeOsteogenesisOsteoporosisParathyroid HormonePremenopauseWnt Signaling PathwayAdaptor Proteins, Signal TransducingCLEC11A protein, humanClec11A protein, mouseHematopoietic Cell Growth FactorsLectins, C-TypeParathyroid HormoneSOST protein, humanosteogenesisosteolectinparathyroid hormonesclerostinstem cells

Identifiers

PMID34140410
PMCPMC8237660
OpenAlexW3167830735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.