Evidence map›Paper›PMID 34140391›Full record

ArticleScience (New York, N.Y.)2021

Plant "helper" immune receptors are Ca

Pierre Jacob, Nak Hyun Kim, Feihua Wu, Farid El-Kasmi, Yuan Chi, William G Walton, Oliver J Furzer, Adam D Lietzan, Sruthi Sunil, Korina Kempthorn and 4 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed
60.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 371 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Diversification and deployment of PRR and NLR immune receptors in potato.The Plant journal : for cell and molecular biology · 2026
    Review
  13. CabioRxiv : the preprint server for biology · 2026
    Article
  14. An Auto-Activated NLR-Protein OsRGA3Plant biotechnology journal · 2026
    Article
  15. Plant NLRs are getting into higher-order architectures.The Plant journal : for cell and molecular biology · 2026
    Review
  16. Article
  17. Subcellular calcium dynamics and organelle perturbations in resistosome-mediated cell death.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Article
  19. Review
  20. Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026
    Review

110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Pierre Jacob *Department of Biology and Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-1253-3256
Nak Hyun Kim *Department of Biology and Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-3722-1988
Feihua WuDepartment of Biology, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-5817-3831
Farid El-KasmiDepartment of Plant Physiology, Centre of Plant Molecular Biology (ZMBP), University of Tübingen, Tübingen, Germany.ORCID 0000-0002-4634-7689
Yuan ChiDepartment of Biology, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-9409-1614
William G WaltonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6745-534X
Oliver J FurzerDepartment of Biology and Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-3536-9970
Adam D LietzanDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6388-2491
Sruthi SunilDepartment of Plant Physiology, Centre of Plant Molecular Biology (ZMBP), University of Tübingen, Tübingen, Germany.
Korina KempthornDepartment of Biology and Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Matthew R RedinboDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-0814-5346
Zhen-Ming PeiDepartment of Biology, Duke University, Durham, NC 27708, USA. zpei@duke.edu lwan@cemps.ac.cn dangl@email.unc.edu.ORCID 0000-0003-1473-696X
Li WanDepartment of Biology and Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. zpei@duke.edu lwan@cemps.ac.cn dangl@email.unc.edu.ORCID 0000-0002-0839-3748
Jeffery L DanglDepartment of Biology and Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. zpei@duke.edu lwan@cemps.ac.cn dangl@email.unc.edu.ORCID 0000-0003-3199-8654
University of North Carolina at Chapel Hill · USDuke University · USUniversity of Tübingen · DEFoshan University · CN

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Structural Basis for Hormone and Neurotransmitter Processing by Gut Microbial EnzymesR01GM135218 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REDINBO, MATTHEW R · 2019 to 2022
$1.5M
Understanding and Controlling Drug Metabolism by the Gut Microbiota to Improve Human HealthR01GM137286 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REDINBO, MATTHEW R · 2020 to 2023
$1.2M
NCI NIH HHS P30 CA016086NIGMS NIH HHS R01 GM135218NIGMS NIH HHS R01 GM137286
6 · The paper itself

Abstract

Plant nucleotide-binding leucine-rich repeat receptors (NLRs) regulate immunity and cell death. In

Indexed as

ArabidopsisArabidopsis ProteinsCalciumCalcium ChannelsCalcium SignalingCell DeathCell MembraneHEK293 CellsHeLa CellsHumansIntracellular Signaling Peptides and ProteinsNLR ProteinsPatch-Clamp TechniquesProtein DomainsProtein Structure, SecondaryADR1 protein, ArabidopsisArabidopsis ProteinsAT5G66900 protein, ArabidopsisCalciumCalcium ChannelsIntracellular Signaling Peptides and ProteinsNLR Proteins

Identifiers

PMID34140391
PMCPMC8939002
OpenAlexW3167479618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.