Evidence map›Paper›PMID 34140355›Full record

ArticleGenes & development2021

Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex.

Lyudmila Dimitrova-Paternoga, Pravin Kumar Ankush Jagtap, Anna Cyrklaff, Vaishali, Karine Lapouge, Peter Sehr, Kathryn Perez, Simone Heber, Christian Löw, Janosch Hennig and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Nucleus Mechanosensing in Cardiomyocytes.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. APC couples neuronal mRNAs to multiple kinesins, EB1, and shrinking microtubule ends for bidirectional mRNA motility.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Emerging Roles of RNA-Binding Proteins in Neurodevelopment.Journal of developmental biology · 2022
    Review
  20. Advances in the study of axon-associated vesicles.Frontiers in molecular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lyudmila Dimitrova-PaternogaDevelopmental Biology Unit, European Molecular Biology Laboratory (EMBL) Heidelberg, 69117 Heidelberg, Germany.
Pravin Kumar Ankush JagtapStructural and Computational Biology Unit, EMBL Heidelberg, 69117 Heidelberg, Germany.
Anna CyrklaffDevelopmental Biology Unit, European Molecular Biology Laboratory (EMBL) Heidelberg, 69117 Heidelberg, Germany.
VaishaliDevelopmental Biology Unit, European Molecular Biology Laboratory (EMBL) Heidelberg, 69117 Heidelberg, Germany.ORCID 0000-0003-0345-924X
Karine LapougeProtein Expression and Purification Core Facility, EMBL Heidelberg, 69117 Heidelberg, Germany.
Peter SehrChemical Biology Core Facility, EMBL Heidelberg, 69117 Heidelberg, Germany.
Kathryn PerezProtein Expression and Purification Core Facility, EMBL Heidelberg, 69117 Heidelberg, Germany.
Simone HeberDevelopmental Biology Unit, European Molecular Biology Laboratory (EMBL) Heidelberg, 69117 Heidelberg, Germany.
Christian LöwCentre for Structural Systems Biology (CSSB), Deutsches Elektronen-Synchrotron (DESY), EMBL Hamburg, 22607 Hamburg, Germany.
Janosch HennigStructural and Computational Biology Unit, EMBL Heidelberg, 69117 Heidelberg, Germany.
Anne EphrussiDevelopmental Biology Unit, European Molecular Biology Laboratory (EMBL) Heidelberg, 69117 Heidelberg, Germany.ORCID 0000-0002-5061-4620
European Molecular Biology Organization · DEDeutsches Elektronen-Synchrotron DESY · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kinesin-1 carries cargos including proteins, RNAs, vesicles, and pathogens over long distances within cells. The mechanochemical cycle of kinesins is well described, but how they establish cargo specificity is not fully understood. Transport of

Indexed as

Drosophila ProteinsKinesinsMicrotubulesRNA, MessengerRNA TransportTropomyosinDrosophila ProteinsKinesinsRNA, MessengerTropomyosinkinesinkinesin adaptorkinesin–atypical tropomyosin complexmRNA transportoskar mRNA

Identifiers

PMID34140355
PMCPMC8247599
OpenAlexW3167172073

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.