Evidence map›Paper›PMID 34140324›Full record

ReviewBMJ open gastroenterology2021

Consensus for the management of pancreatic exocrine insufficiency: UK practical guidelines.

Mary E Phillips, Andrew D Hopper, John S Leeds, Keith J Roberts, Laura McGeeney, Sinead N Duggan, Rajesh Kumar

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in BMJ open gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06756503 (Prevalence and Clinical Characteristics of Exocrine Pancreatic Insufficiency in Patients With Functional Dyspepsia), which is not on this map. Cited by 70 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 9 pooled it
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06756503 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Prevalence and Clinical Characteristics of Exocrine Pancreatic Insufficiency in Patients With Functional Dyspepsia

TypeobservationalSponsorMaria Marta PiskorzRan2025 to 2026Enrolled65ConditionsExocrine Pancreatic Insufficiency, DyspepsiaArmsfecal elastase, Serum cytokines
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 9 syntheses or guidelines pooled it, 145 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Guidelines on optimizing the use of proton pump inhibitors: PPI stewardship.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023
    Guideline
  10. Trial
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Pancreatic enzyme replacement therapy for exocrine pancreatic insufficiency-Insights into prescribing practices.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Article
  17. Review
  18. Article
  19. Review
  20. Pancreatic cancer.Nature reviews. Disease primers · 2026
    Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Mary E PhillipsNutrition and Dietetics, Royal Surrey Hospital NHS Foundation Trust, Guildford, UK mary.phillips1@nhs.net.ORCID 0000-0002-9033-9993
Andrew D HopperDepartment of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
John S LeedsHPB Unit, Freeman Hospital, Newcastle Upon Tyne, Tyne and Wear, UK.ORCID 0000-0002-5140-6225
Keith J RobertsHPB Surgery, Queen Elizabeth Hospital Birmingham, Birmingham, UK.ORCID 0000-0003-1799-9829
Laura McGeeneyNutrition and Dietetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Sinead N DugganDepartment of Surgery, Trinity College Dublin, Dublin, Ireland.
Rajesh KumarHPB Surgery, Royal Surrey Hospital NHS Foundation Trust, Guildford, UK.
Royal Surrey NHS Foundation Trust · GBCambridge University Hospitals NHS Foundation Trust · GBFreeman Hospital · GBQueen Elizabeth Hospital Birmingham · GBSheffield Teaching Hospitals NHS Foundation Trust · GBTrinity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPancreatic exocrine insufficiency is a finding in many conditions, predominantly affecting those with chronic pancreatitis, pancreatic cancer and acute necrotising pancreatitis. Patients with pancreatic exocrine insufficiency can experience gastrointestinal symptoms, maldigestion, malnutrition and adverse effects on quality of life and even survival.There is a need for readily accessible, pragmatic advice for healthcare professionals on the management of pancreatic exocrine insufficiency. METHODS AND ANALYSIS: A review of the literature was conducted by a multidisciplinary panel of experts in pancreatology, and recommendations for clinical practice were produced and the strength of the evidence graded. Consensus voting by 48 pancreatic specialists from across the UK took place at the 2019 Annual Meeting of the Pancreatic Society of Great Britain and Ireland annual scientific meeting.

resultsRecommendations for clinical practice in the diagnosis, initial management, patient education and long term follow up were developed. All recommendations achieved over 85% consensus and are included within these comprehensive guidelines.

Indexed as

Exocrine Pancreatic InsufficiencyPancreatitis, ChronicConsensusHumansQuality of LifeUnited Kingdomexocrine pancreatic functionpancreaspancreatic disorderspancreatic enzymes

Identifiers

PMID34140324
PMCPMC8212181
OpenAlexW3171383836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.