Evidence map›Paper›PMID 34140221›Full record

ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2021

Immune response to COVID-19 in older adults.

Mladen Jergović, Christopher P Coplen, Jennifer L Uhrlaub, Janko Nikolich-Žugich

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. One-year follow-up of depression, anxiety, and quality of life of Peruvian patients who survived COVID-19.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
  6. Adaptive Immunity to Viruses: What Did We Learn from SARS-CoV-2 Infection?International journal of molecular sciences · 2022
    Review
  7. Observational
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mladen JergovićDepartment of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, Arizona; University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, Arizona. Electronic address: mjergovic@arizona.edu.
Christopher P CoplenDepartment of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, Arizona; University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, Arizona.
Jennifer L UhrlaubDepartment of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, Arizona; University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, Arizona.
Janko Nikolich-ŽugichDepartment of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, Arizona; University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, Arizona.
University of Arizona · US

Funding

Thymic and Peripheral Aspects of T Cell Aging and RejuvenationP01AG052359 · NIA · UNIVERSITY OF ARIZONA · PI JANKO Z. NIKOLICH · 2017 to 2026
$23.5M
T Cell Homeostasis and Function in Immune SenescenceR37AG020719 · NIA · UNIVERSITY OF ARIZONA · PI JANKO Z. NIKOLICH · 2018 to 2026
$4.2M
T Cell Homeostasis and Function in Immune SenescenceR01AG020719 · NIA · UNIVERSITY OF ARIZONA · PI NIKOLICH, JANKO Z. · 2001 to 2012
$3.1M
Mechanisms of age-related susceptibility to the chikungunya virus (CHIKV)R01AG057701 · NIA · UNIVERSITY OF ARIZONA · PI NIKOLICH, JANKO Z. · 2018 to 2022
$1.7M
NIA NIH HHS P01 AG052359NIA NIH HHS R01 AG020719NIA NIH HHS R01 AG057701NIA NIH HHS R37 AG020719
6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third highly pathogenic coronavirus to emerge in the human population in last two decades. SARS-CoV-2 spread from Wuhan, China, across the globe, causing an unprecedented public healthcare crisis. The virus showed remarkable age dependent pathology, with symptoms resembling common cold in most adults and children while causing more severe respiratory distress and significant mortality in older and frail humans. Even before the SARS-CoV-2 outbreak infectious diseases represented one of the major causes of death of older adults. Loss of immune function and reduced protection from infectious agents with age - immunosenescence - is a result of complex mechanisms affecting production and maintenance of immune cells as well as the initiation, maintenance and termination of properly directed immune responses. Here we briefly discuss the current knowledge on how this process affects age-dependent outcomes of SARS-CoV-2 infection.

Indexed as

ImmunityAgedAge FactorsCOVID-19HumansagingCOVID-19immunitySars-CoV-2severity

Identifiers

PMID34140221
PMCPMC8111884
OpenAlexW3161328564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.