Observational studyBMC pulmonary medicine2021
Mechanical power normalized to lung-thorax compliance predicts prolonged ventilation weaning failure: a prospective study.
Observational study in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Effect of automated versus conventional ventilation on mechanical power of ventilation-A randomized crossover clinical trial.PloS one · 2024Trial
- Trial
- Minimum observation time to determine ventilator liberation success and its associated factors in tracheostomized patients in intensive and high-care units in Japan: a single-center retrospective study.Acute and critical care · 2026Article
- Mechanical power normalized to dynamic lung compliance as a predictor of weaning and prognosis in mechanically ventilated patients: a retrospective cohort study.BMC anesthesiology · 2025Observational
- Mechanical Power to Predict Ventilator Liberation in Patients With a Tracheostomy.Respiratory care · 2025Article
- The association of ventilator mechanical power with weaning outcomes in intensive care unit patients: a narrative review.Journal of thoracic disease · 2025Review
- Bedside Assessment of the Respiratory System During Invasive Mechanical Ventilation.Journal of clinical medicine · 2024Review
- Weaning Failure in Elderly Patients: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Mechanical power density, spontaneous breathing indexes, and prolonged weaning failure: a prospective cohort study.Scientific reports · 2024Observational
- Article
- Accuracy of calculating mechanical power of ventilation by one commonly used equation.Journal of clinical monitoring and computing · 2022Article
- Mechanical power is associated with weaning outcome in critically ill mechanically ventilated patients.Scientific reports · 2022Article
- Mechanical power normalized to lung-thorax compliance indicates weaning readiness in prolonged ventilated patients.Scientific reports · 2022Observational
- Tracheal stenosis in prolonged mechanically ventilated patients: prevalence, risk factors, and bronchoscopic management.BMC pulmonary medicine · 2022Observational
- Incidence, causes, and predictors of unsuccessful decannulation following prolonged weaning.Therapeutic advances in chronic disease · 2022Article
- Ventilatory ratio and mechanical power in prolonged mechanically ventilated COVID-19 patientsTherapeutic advances in respiratory diseaseObservational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMechanical power (MP) of artificial ventilation, the energy transferred to the respiratory system, is a chief determinant of adequate oxygenation and decarboxylation. Calculated MP, the product of applied airway pressure and minute ventilation, may serve as an estimate of respiratory muscle workload when switching to spontaneous breathing. The aim of the study was to assess MP's discriminatory performance in predicting successful weaning from prolonged tracheostomy ventilation.
methodsProspective, observational study in 130 prolonged mechanically ventilated, tracheotomized patients in a specialized weaning center. Predictive weaning outcome ability of arterial blood gas analyses and indices derived from calculated MP at beginning and end of weaning was determined in terms of area under receiver operating characteristic curve (AUROC) and measures derived from k-fold cross-validation (likelihood ratios, diagnostic odds ratio, F
resultsForty-four (33.8%) patients experienced weaning failure. Absolute MP showed poor discrimination in predicting outcome; whereas specific MP (MP normalized to dynamic lung-thorax compliance, LTC
conclusionsMP normalized to dynamic lung-thorax compliance, a surrogate for applied power per unit of ventilated lung volume, accurately discriminated between low and high risk for weaning failure following prolonged mechanical ventilation.
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