Evidence map›Paper›PMID 34140006›Full record

SynthesisBMC medicine2021

A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study.

Louise Rose, Lisa Burry, Meera Agar, Bronagh Blackwood, Noll L Campbell, Mike Clarke, John W Devlin, Jacques Lee, John C Marshall, Dale M Needham and 2 more

Open access · goldAbstract readSystematic ReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Review
  9. The Neuropsychiatric Disturbances of Delirium: A Review of Syndromes and Their Treatment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Advancing specificity in delirium: The delirium subtyping initiative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 4 countries.

Louise RoseFlorence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, Rm 1.13, James Clerk Maxwell Building, 57 Waterloo Rd, London, SE1 8WA, UK. louise.rose@kcl.ac.uk.ORCID 0000-0003-1700-3972
Lisa BurryLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
Meera AgarFaculty of Health, University of Technology Sydney, Sydney, Australia.
Bronagh BlackwoodWellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK.
Noll L CampbellCollege of Pharmacy, Purdue University, West Lafayette, IN, USA.
Mike ClarkeSchool of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland.
John W DevlinSchool of Pharmacy, Northeastern University, Boston, MA, USA.
Jacques LeeInaugural Research Chair in Geriatric Emergency Medicine, Schwartz/Reisman Emergency Medicine Institute, Sinai Health System, Toronto, Ontario, Canada.
John C MarshallSt Michael's Hospital and Li Ka Shing Research Institute, Toronto, Canada.
Dale M NeedhamSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Najma SiddiqiHull York Medical School, University of York, York, UK.
Valerie PageWatford General Hospital, Watford, UK.
Queen's University Belfast · GBJohns Hopkins University · USKing's College London · GBMount Sinai Hospital · CANortheastern University · USPurdue University West Lafayette · USSinai Health System · CASt. Michael's Hospital · CAUniversity of Technology Sydney · AUUniversity of York · GBWatford General Hospital · GB

Funding

Supplement to Network for Investigation of Delirium across the U.S (NIDUS)R24AG054259 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2016 to 2020
$4.3M
Medical Research Council G0901530NIA NIH HHS R24 AG054259
6 · The paper itself

Abstract

backgroundTrials of interventions to prevent or treat delirium in adults in an acute hospital setting report heterogeneous outcomes. Our objective was to develop international consensus among key stakeholders for a core outcome set (COS) for future trials of interventions to prevent and/or treat delirium in adults with an acute care hospital admission and not admitted to an intensive care unit.

methodsA rigorous COS development process was used including a systematic review, qualitative interviews, modified Delphi consensus process, and in-person consensus using nominal group technique (registration http://www.comet - initiative.org/studies/details/796 ). Participants in qualitative interviews were delirium survivors or family members. Participants in consensus methods comprised international representatives from three stakeholder groups: researchers, clinicians, and delirium survivors and family members.

resultsItem generation identified 8 delirium-specific outcomes and 71 other outcomes from 183 studies, and 30 outcomes from 18 qualitative interviews, including 2 that were not extracted from the systematic review. De-duplication of outcomes and formal consensus processes involving 110 experts including researchers (N = 32), clinicians (N = 63), and delirium survivors and family members (N = 15) resulted in a COS comprising 6 outcomes: delirium occurrence and reoccurrence, delirium severity, delirium duration, cognition, emotional distress, and health-related quality of life. Study limitations included exclusion of non-English studies and stakeholders and small representation of delirium survivors/family at the in-person consensus meeting.

conclusionsThis COS, endorsed by the American and Australian Delirium Societies and European Delirium Association, is recommended for future clinical trials evaluating delirium prevention or treatment interventions in adults presenting to an acute care hospital and not admitted to an intensive care unit.

Indexed as

DeliriumQuality of LifeAdultAustraliaDelphi TechniqueHospitalsHumansResearch DesignTreatment OutcomeClinical trialsCore outcome setDeliriumHospitalization

Identifiers

PMID34140006
PMCPMC8211534
OpenAlexW3172172702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.