Evidence map›Paper›PMID 34139961›Full record

ArticleEmerging microbes & infections2021

Potential role of vector-mediated natural selection in dengue virus genotype/lineage replacements in two epidemiologically contrasted settings.

Olivia O'Connor, Tey Putita Ou, Fabien Aubry, Stéphanie Dabo, Sylvie Russet, Dominique Girault, Saraden In, Marine Minier, Sebastian Lequime, Thavry Hoem and 7 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Vector competence acrossJournal of virology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Climate, demography, immunology, and virology combine to drive two decades of dengue virus dynamics in Cambodia.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Article
  13. National dengue surveillance, Cambodia 2002-2020.Bulletin of the World Health Organization · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Olivia O'ConnorDengue and Arboviruses Research and Expertise Unit, Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, Noumea, New Caledonia.ORCID https://orcid.org/0000-0002-8108-8408
Tey Putita OuVirology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
Fabien AubryInsect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
Stéphanie DaboInsect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
Sylvie RussetDengue and Arboviruses Research and Expertise Unit, Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, Noumea, New Caledonia.
Dominique GiraultDengue and Arboviruses Research and Expertise Unit, Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, Noumea, New Caledonia.
Saraden InVirology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
Marine MinierMedical Entomology Research and Expertise Unit, Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, Noumea, New Caledonia.
Sebastian LequimeInsect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
Thavry HoemVirology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
Sébastien BoyerMedical Entomology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
Philippe DussartVirology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.ORCID https://orcid.org/0000-0002-1931-3037
Nicolas PocquetMedical Entomology Research and Expertise Unit, Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, Noumea, New Caledonia.
Valérie Burtet-SarramegnaInstitute For Exact and Applied Sciences, Université de la Nouvelle-Calédonie, Noumea, New Caledonia.
Louis LambrechtsInsect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.ORCID https://orcid.org/0000-0001-5958-2138
Veasna DuongMedical Entomology Research and Expertise Unit, Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, Noumea, New Caledonia.ORCID https://orcid.org/0000-0003-0353-1678
Myrielle Dupont-RouzeyrolDengue and Arboviruses Research and Expertise Unit, Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, Noumea, New Caledonia.ORCID https://orcid.org/0000-0002-6991-4893

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus (DENV) evolutionary dynamics are characterized by frequent DENV genotype/lineage replacements, potentially associated with changes in disease severity and human immunity. New Caledonia (NC) and Cambodia, two contrasted epidemiological settings, respectively experienced a DENV-1 genotype IV to I replacement in 2012 and a DENV-1 genotype I lineage 3-4 replacement in 2005-2007, both followed by a massive dengue outbreak. However, their underlying evolutionary drivers have not been elucidated. Here, we tested the hypothesis that these genotype/lineage switches reflected a higher transmission fitness of the replacing DENV genotype/lineage in the mosquito vector using

Indexed as

Selection, GeneticAedesAnimalsCambodiaDengueDengue VirusDisease OutbreaksGenetic FitnessGenotypeHumansMosquito VectorsNew CaledoniaPhylogenySalivaAedes aegypticompetition assayDengue virusgenotype/lineage replacementtransmission fitness

Identifiers

PMID34139961
PMCPMC8259877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.