Evidence map›Paper›PMID 34139914›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Targeting allosteric sites of human aromatase: a comprehensive

Hani A Alhadrami, Ahmed M Sayed, Sami A Melebari, Asem A Khogeer, Wesam H Abdulaal, Mohamed B Al-Fageeh, Mohammad Algahtani, Mostafa E Rateb

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Hani A AlhadramiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Ahmed M SayedDepartment of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt.
Sami A MelebariMolecular Diagnostic Unit, The Regional Laboratory in Makkah, Ministry of Health, Makkah, Kingdom of Saudi Arabia.
Asem A KhogeerPlan and Research Department, General Directorate of Health Affairs, Makkah region, Ministry of Health, Makkah, Kingdom of Saudi Arabia.
Wesam H AbdulaalDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Mohamed B Al-FageehGeneral Directorate for Funds and Grants (GDFG), King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Mohammad AlgahtaniDepartment of Laboratory and Blood Bank, Security Forces Hospital Program, Mecca, Saudi Arabia.
Mostafa E RatebSchool of Computing, Engineering & Physical Sciences, University of the West of Scotland, Paisley, UK.
Ministry of Health · SAHera General Hospital · SAKing Abdulaziz City for Science and Technology · SAKing Abdulaziz University · SANahda University · EGSecurity Forces Hospital · SAUniversity of the West of Scotland · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent findings suggested several allosteric pockets on human aromatase that could be utilised for the development of new modulators able to inhibit this enzyme in a new mechanism. Herein, we applied an integrated

Indexed as

Allosteric RegulationAromataseBreast NeoplasmsComputer SimulationDrug Screening Assays, AntitumorFemaleHumansAromataseallosteric inhibitionanti-breast cancerAromatasein siliconatural products

Identifiers

PMID34139914
PMCPMC8759730
OpenAlexW3171845501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.