ArticleBone & joint open2021
The association of preoperative blood markers with postoperative readmissions following arthroplasty.
Article in Bone & joint open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Perioperative hyponatremia in total joint arthroplasty: A systematic review of prevalence, risk factors, outcomes, and management.Journal of orthopaedics · 2026Review
- Preoperative Hypoalbuminemia Predicts Infection, Fracture, and Repeat Revision After Revision Total Hip Arthroplasty; Prealbumin Stratification Does Not Refine Risk: A Retrospective Database Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Associations of preoperative hematocrit and platelet count with morbidity after pathologic fracture fixation.Journal of bone oncology · 2025Article
- Hemoglobin-to-RDW ratio, hemoglobin-to-monocyte ratio, and hemoglobin-to-leukocyte ratio are predictive of 14-day readmission after primary total knee arthroplasty.Journal of orthopaedic surgery and research · 2024Article
- Predicting 30-day unplanned hospital readmission after revision total knee arthroplasty: machine learning model analysis of a national patient cohort.Medical & biological engineering & computing · 2024Article
- Preoperative demographics and laboratory markers may be associated with early dislocation after total hip arthroplasty.Journal of experimental orthopaedics · 2023Article
- The Prognostic Role of Preoperative Hematological and Inflammatory Indices in Canine Appendicular Osteosarcoma.Veterinary sciences · 2023Article
- Alkaline Phosphatase is an Independent Risk Factor for Periprosthetic Fractures in Total Joint Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2023Article
- Preoperative Malnutrition and Metabolic Markers May Predict Periprosthetic Fractures in Total Hip Arthroplasty.Arthroplasty today · 2023Article
- Abnormal preoperative platelet count may predict postoperative complications following shoulder arthroplasty.JSES international · 2022Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWhile preoperative bloodwork is routinely ordered, its value in determining which patients are at risk of postoperative readmission following total knee arthroplasty (TKA) and total hip arthroplasty (THA) is unclear. The objective of this study was to determine which routinely ordered preoperative blood markers have the strongest association with acute hospital readmission for patients undergoing elective TKA and THA.
methodsTwo population-based retrospective cohorts were assembled for all adult primary elective TKA (n = 137,969) and THA (n = 78,532) patients between 2011 to 2018 across 678 North American hospitals using the American College of Surgeons National Quality Improvement Programme (ACS-NSQIP) registry. Six routinely ordered preoperative blood markers - albumin, haematocrit, platelet count, white blood cell count (WBC), estimated glomerular filtration rate (eGFR), and sodium level - were queried. The association between preoperative blood marker values and all-cause readmission within 30 days of surgery was compared using univariable analysis and multivariable logistic regression adjusted for relevant patient and treatment factors.
resultsThe mean TKA age was 66.6 years (SD 9.6) with 62% being females (n = 85,163/137,969), while in the THA cohort the mean age was 64.7 years (SD 11.4) with 54% being female (n = 42,637/78,532). In both cohorts, preoperative hypoalbuminemia (< 35 g/l) was associated with a 1.5- and 1.8-times increased odds of 30-day readmission following TKA and THA, respectively. In TKA patients, decreased eGFR demonstrated the strongest association with acute readmission with a standardized odds ratio of 0.75 per two standard deviations increase (p < 0.0001).
conclusionIn this population level cohort analysis of arthroplasty patients, low albumin demonstrated the strongest association with acute readmission in comparison to five other commonly ordered preoperative blood markers. Identification and optimization of preoperative hypoalbuminemia could help healthcare providers recognize and address at-risk patients undergoing TKA and THA. This is the most comprehensive and rigorous examination of the association between preoperative blood markers and readmission for TKA and THA patients to date. Cite this article:
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