ArticleJournal of the American Heart Association2021
Burden of Ischemic Stroke in Patients With Congenital Heart Disease: A Nationwide, Case-Control Study.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of stroke in patients with congenital heart disease: a systematic review and meta-analysis.BMC neurology · 2024Pooled it
- From Minor Monitoring to Major Insight: Predicting AF Development in the Congenital Heart Disease Population.Journal of cardiovascular development and disease · 2026Article
- Point of care INR monitoring in cyanotic congenital heart disease-related compensatory erythrocytosis.International journal of cardiology. Congenital heart disease · 2026Article
- Clinical Features and Outcomes of Ischemic Stroke among Young Filipino Adults.Acta medica Philippina · 2026Article
- Long-term outcome after surgical ventricular septal defect closure: Longitudinal follow-up into the fifth decade.International journal of cardiology. Congenital heart disease · 2025Article
- Seizures in Infants With Congenital Heart Disease: A National Cohort Study.Journal of the American Heart Association · 2025Article
- Standardized mortality ratio in adults with congenital heart disease.European heart journal open · 2025Article
- Review
- Association of cataract surgery with stroke among older adults in the United States.Eye (London, England) · 2025Article
- Primary Ciliary Dyskinesia Complicated by Stroke in an Elderly Male: A Case Report.Respirology case reports · 2025Article
- Perioperative Brain Injury in Children with Aortic Arch Anomalies: A Retrospective Study of Risk Factors and Outcomes.Pediatric cardiology · 2024Article
- Ischemic Stroke in Adults With Congenital Heart Disease: Cumulative Incidence and Associated Factors.Journal of the American Heart Association · 2024Article
- Reducing Rates and Risk of Stroke in Adults With Congenital Heart Disease: What Can We Do Now, and What Should We Do Next?Journal of the American Heart Association · 2024Article
- Incidence and Predictors of Stroke in Australian Adults With Congenital Heart Disease (2000-2017).Journal of the American Heart Association · 2024Article
- "We have dealt with so much. There's more coming?": Improving Knowledge About Brain Health in Adults Living With Congenital Heart Disease.CJC pediatric and congenital heart disease · 2024Article
- SomaticExperimental and therapeutic medicine · 2024Article
- Discovery ofAmerican journal of translational research · 2024Article
- Association Between Congenital Heart Disease and Stroke: Insights from a National Database.Pediatric cardiology · 2024Article
- Unroofed Coronary Sinus as Potential Cause of Ischemic Stroke Following Left Atrial Appendage Closure.JACC. Case reports · 2023Article
- Coarctation of the Aorta: Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Patients with congenital heart disease (CHD) are at increased risk of developing ischemic stroke (IS) compared with controls without CHD. However, the long-term outcomes after IS, including IS recurrence and mortality risk, remain unclear. Methods and Results We identified all patients with CHD in Sweden who were born between 1930 and 2017 using the Swedish National Patient Register and the Cause of Death Register. Ten controls without CHD were randomly selected from the general population and matched for birth year and sex for each patient with CHD. The follow-up of the study population was performed between January 1970 and December 2017. In total, 88 700 patients with CHD (50.6% men) and 890 450 matched controls (51.0%) were included in this study. During a mean follow-up of 25.1±22.0 years, patients with CHD had a 5-fold higher risk of developing an index IS (hazard ratio [HR], 5.01; 95% CI, 4.81-5.22) compared with controls. However, the risk of developing a recurrent IS was lower in patients with CHD compared with controls (HR, 0.66; 95% CI, 0.56-0.78), an observation that persisted after adjustment for cardiovascular risk factors and comorbidities. Patients with CHD were also at a significantly lower risk of all-cause mortality after index IS than controls (HR, 0.53; 95% CI, 0.49-0.58). Conclusions Patients with CHD had a 5-fold higher risk of developing index IS compared with matched controls. However, the risk of recurrent IS stroke and all-cause mortality were 34% and 47% lower, respectively, in patients with CHD compared with controls.
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