Evidence map›Paper›PMID 34139845›Full record

ArticleBioconjugate chemistry2021

NIR Fluorescent Imaging and Photodynamic Therapy with a Novel Theranostic Phospholipid Probe for Triple-Negative Breast Cancer Cells.

Natalia I Rubtsova, Michael C Hart, Alejandro D Arroyo, Sofya A Osharovich, Benjamin K Liebov, Joann Miller, Min Yuan, Jeffrey M Cochran, Sanghoon Chong, Arjun G Yodh and 4 more

Open access · greenAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Cancer Cell-Specific Fluorescent Prodrug Delivery Platforms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Chemical Probes and Activity-Based Protein Profiling for Cancer Research.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Natalia I RubtsovaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, United States.
Michael C HartDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, United States.
Alejandro D ArroyoDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, United States.
Sofya A OsharovichDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, United States.
Benjamin K LiebovDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, United States.
Joann MillerDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Bldg 421, Philadelphia, Pennsylvania 19104, United States.
Min YuanDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Bldg 421, Philadelphia, Pennsylvania 19104, United States.
Jeffrey M CochranDepartment of Physics and Astronomy, University of Pennsylvania, 3231 Walnut Street, Philadelphia, Pennsylvania 19104, United States.
Sanghoon ChongDepartment of Physics and Astronomy, University of Pennsylvania, 3231 Walnut Street, Philadelphia, Pennsylvania 19104, United States.
Arjun G YodhDepartment of Physics and Astronomy, University of Pennsylvania, 3231 Walnut Street, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-4744-2706
Theresa M BuschDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Bldg 421, Philadelphia, Pennsylvania 19104, United States.
E James DelikatnyDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, United States.
Nadia AnikeevaDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.
Anatoliy V PopovDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-4678-6307
University of Pennsylvania · USThomas Jefferson University · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Near-infrared Choline Kinase Sensors for Intraoperative Identification of Lung Tumor MarginsR01CA226412 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DELIKATNY, EDWARD J, SINGHAL, SUNIL · 2018 to 2022
$1.8M
Targeted treatment for radiculopathy via engineered PLA2-responsive multifunctional micellesR01NS100892 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CHENG, ZHILIANG · 2017 to 2021
$1.7M
Phospholipase-activated theranostics for PDT of breast cancerR01CA201328 · NCI · UNIVERSITY OF PENNSYLVANIA · PI POPOV, ANATOLIY VELTEROVICH · 2016 to 2019
$1.5M
Cerenkov imaging for in vivo pH determination of the tumor microenvironmentF31CA206453 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ARROYO PACHECO, ALEJANDRO D. · 2016 to 2018
$106k
NCI NIH HHS F31 CA206453NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA201328NCI NIH HHS R01 CA226412NINDS NIH HHS R01 NS100892
6 · The paper itself

Abstract

New exogenous probes are needed for both imaging diagnostics and therapeutics. Here, we introduce a novel nanocomposite near-infrared (NIR) fluorescent imaging probe and test its potency as a photosensitizing agent for photodynamic therapy (PDT) against triple-negative breast cancer cells. The active component in the nanocomposite is a small molecule, pyropheophorbide

Indexed as

PhotochemotherapyCell Line, TumorCell ProliferationCell SurvivalDrug DesignHumansLipidsMolecular StructureNanoparticlesPhospholipidsSpectrophotometry, InfraredTriple Negative Breast NeoplasmsLipidsPhospholipids

Identifiers

PMID34139845
PMCPMC12990043
OpenAlexW3168659349

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.