Evidence map›Paper›PMID 34139761›Full record

ArticleThe Journal of infectious diseases2022

Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis.

Arnau Casanovas-Massana, Daiana de Oliveira, Andrew G Schneider, Mike Begon, James E Childs, Federico Costa, Mitermayer G Reis, Albert I Ko, Elsio A Wunder

Open access · greenAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Leptospirosis.Nature reviews. Disease primers · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Leptospirosis and Coinfection: Should We Be Concerned?International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Arnau Casanovas-MassanaYale School of Public Health, New Haven, Connecticut, USA.
Daiana de OliveiraOswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Andrew G SchneiderYale School of Public Health, New Haven, Connecticut, USA.
Mike BegonInstitute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
James E ChildsYale School of Public Health, New Haven, Connecticut, USA.
Federico CostaYale School of Public Health, New Haven, Connecticut, USA.
Mitermayer G ReisYale School of Public Health, New Haven, Connecticut, USA.
Albert I KoYale School of Public Health, New Haven, Connecticut, USA.
Elsio A WunderYale School of Public Health, New Haven, Connecticut, USA.ORCID 0000-0002-5239-8511
Fundação Oswaldo Cruz · BRUniversidade Federal da Bahia · BRUniversity of Liverpool · GB

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Naturally-Acquired and Vaccine-Mediated Immunity to LeptospirosisR01AI121207 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG, REIS, MITERMAYER GALVAO DOS · 2016 to 2020
$6.4M
Global Health Fellows and Scholars Research TrainingR25TW009338 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARRY, MICHELE, KO, ALBERT ICKSANG · 2012 to 2016
$5.2M
Disease Determinants of Urban LeptospirosisU01AI088752 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG · 2010 to 2014
$3.6M
Natural History of Urban LeptospirosisR01AI052473 · NIAID · YALE UNIVERSITY · PI KO, ALBERT ICKSANG · 2003 to 2013
$2.8M
Ecoepidemiology of leptospirosis in the urban slums of BrazilR01TW009504 · FIC · YALE UNIVERSITY · PI BEGON, MICHAEL, CHILDS, JAMES EMORY · 2012 to 2016
$2.2M
FIC NIH HHS D43 TW010540FIC NIH HHS R01 TW009504FIC NIH HHS R25 TW009338NIAID NIH HHS R01 AI052473NIAID NIH HHS R01 AI121207NIAID NIH HHS U01 AI088752Wellcome TrustWellcome Trust 102330/Z/13/Z
6 · The paper itself

Abstract

In this study, we genotyped samples from environmental reservoirs (surface water and soil), colonized rat specimens, and cases of human severe leptospirosis from an endemic urban slum in Brazil, to determine the molecular epidemiology of pathogenic Leptospira and identify pathways of leptospirosis infection. We identified a well-established population of Leptospira interrogans serovar Copenhageni common to human leptospirosis cases, and animal and environmental reservoirs. This finding provides genetic evidence for a potential environmental spillover pathway for rat-borne leptospirosis through the environment in this urban community and highlights the importance of environmental and social interventions to reduce spillover infections.

Indexed as

EnvironmentSoil MicrobiologyWater MicrobiologyAmplified Fragment Length Polymorphism AnalysisAnimalsBrazilHumansLeptospiraLeptospira interrogansLeptospirosisMolecular EpidemiologyPhylogenyRatsSequence Analysis, DNAenvironmental reservoirgenotypingLeptospira interrogansleptospirosispathogenic LeptospiraRattus norvegicussoilwater

Identifiers

PMID34139761
PMCPMC8730487
OpenAlexW3171741473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.