Evidence map›Paper›PMID 34139631›Full record

ArticleJournal of autoimmunity2021

Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines.

Jimin Hwang, Se Bee Lee, Seung Won Lee, Min Ho Lee, Ai Koyanagi, Louis Jacob, Kalthoum Tizaoui, Dong Keon Yon, Jae Il Shin, Lee Smith

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of autoimmunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Demystifying autoimmune HIT: what it is, when to test, and how to treat.Hematology. American Society of Hematology. Education Program · 2024
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Stroke Associated with COVID-19 Vaccines.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Adenovirus vector-based vaccine for infectious diseases.Drug metabolism and pharmacokinetics · 2022
    Review
  19. Post COVID-19 Vaccination-Associated Neurological Complications.Neuropsychiatric disease and treatment · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 6 countries.

Jimin HwangDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Se Bee LeeUlsan University College of Medicine, Seoul, Republic of Korea.
Seung Won LeeDepartment of Data Science, Sejong University College of Software Convergence, Seoul, South Korea.
Min Ho LeeYonsei University College of Medicine, Seoul, Republic of Korea.
Ai KoyanagiParc Sanitari Sant Joan de Deu/CIBERSAM, Universitat de Barcelona, Fundacio Sant Joan de Deu, Sant Boi de Llobregat, Barcelona, Spain; ICREA, Pg. Lluis Companys 23, Barcelona, Spain.
Louis JacobParc Sanitari Sant Joan de Deu/CIBERSAM, Universitat de Barcelona, Fundacio Sant Joan de Deu, Sant Boi de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain; Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.
Kalthoum TizaouiLaboratory of Microoranismes and Active Biomolecules, Sciences Faculty of Tunis, Tunis El Manar University, Tunis, Tunisia.
Dong Keon YonDepartment of Pediatrics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: yonkkang@gmail.com.
Jae Il ShinDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: shinji@yuhs.ac.
Lee SmithThe Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK.
Yonsei University · KRAnglia Ruskin University · GBInstitució Catalana de Recerca i Estudis Avançats · ESJohns Hopkins University · USSejong University · KRSeoul National University Hospital · KRTunis El Manar University · TNUniversité de Versailles Saint-Quentin-en-Yvelines · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral venous thrombosis (CVT) events have been reported after vaccination with adenoviral COVID-19 vector vaccines. This study aimed to compare the clinical presentations and courses of vaccine-induced thrombotic thrombocytopenia (VITT) between the two adenoviral vector vaccines, Ad26.COV.2.S (Janssen/Johnson & Johnson) and ChAdOx1 nCoV-19 (Astra-Zeneca). We found that CVT after Ad26.COV.2.S vaccination presents later with similar symptoms compared to CVT after administration of ChAdOx1 nCoV-19, albeit with more thrombosis and intracerebral hemorrhage, lower D-dimer and aPTT levels but similar mortality. These findings could help guide clinical assessment and management of CVT after COVID-19 vaccination.

Indexed as

Ad26COVS1ChAdOx1 nCoV-19COVID-19COVID-19 VaccinesHumansSARS-CoV-2Venous ThrombosisAd26COVS1ChAdOx1 nCoV-19COVID-19 VaccinesAdenoviral vector vaccineCerebral venous thrombosisCOVID-19 vaccineThrombotic thrombocytopenia syndromeVaccine-induced thrombotic thrombocytopenia

Identifiers

PMID34139631
PMCPMC8204660
OpenAlexW3167101822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.